| Comparison of four perioperative misoprostol regimens for surgical termination of first-trimester pregnancy. | |
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MedLine Citation:
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PMID: 19747679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the outcomes of 4 different perioperative misoprostol regimens for surgical termination of first-trimester pregnancy. METHODS: Retrospective analysis of the records of 4000 women (4 cohorts of 1000 each) who underwent surgical termination of pregnancy. The 4 cohorts received: no misoprostol; 200 microg of oral misoprostol 30 minutes preoperatively; 200 microg of sublingual misoprostol 30 minutes preoperatively; or 200 microg of oral misoprostol 3 hours preoperatively plus 200 microg of vaginal misoprostol postoperatively. Adverse effects of the last regimen were surveyed in 1000 women. RESULTS: In the cohorts that received misoprostol, the difficulty of cervical dilatation was reduced (P<0.001) compared with the cohort of women that did not receive misoprostol. The frequency with which women made postoperative contacts with the clinic was also reduced in the cohorts that received misoprostol (P<0.05). Adverse effects were minimal. CONCLUSIONS: This retrospective study showed an association between perioperative administration of misoprostol, reduced difficulty for operators, and reduced demand for postoperative care. The regimen associated with the greatest reduction in difficult cervical dilatations and postoperative consultations was 200 microg of oral misoprostol 3 hours preoperatively plus 200 microg of misoprostol vaginally at the end of the surgical procedure. |
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Authors:
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Dennis G Chambers; Ea C Mulligan; Anthony R Laver; Bronwen K Weller; Jane K Baird; Wye Y Herbert |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-09-10 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 107 ISSN: 1879-3479 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 211-5 Citation Subset: IM |
Affiliation:
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The Queen Elizabeth Hospital Pregnancy Advisory Centre, Woodville Park, Adelaide, South Australia. dennis.chambers@health.sa.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage* Abortion, Induced* Administration, Intravaginal Administration, Sublingual Drug Administration Schedule Female Humans Misoprostol / administration & dosage* Perioperative Care* Pregnancy Pregnancy Trimester, First Retrospective Studies Vacuum Curettage* |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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