Document Detail

Comparison of four methods for measuring elevation of FRC in mechanically ventilated infants.
MedLine Citation:
PMID:  10551968     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to compare measurements of the elevation of functional residual capacity (FRC) above the relaxation volume obtained in 34 mechanically ventilated infants (median weight 2.6 kg, range 1.2-9) from four different methods: (1) direct measurement of the complete exhalation volume after brief disconnection from the ventilator, (2) calculated measurement from total positive end-expiratory pressure (PEEP) measured by end-expiratory occlusion of the breathing circuit, (3) extrapolated evaluation from the mathematical model of Brody, (4) extrapolated evaluation from the passive expiration method. We considered the direct measurement (1) as the "gold standard". Measurements obtained by total PEEP (2) and by the Brody's mathematical model (3) provided similar results than the direct measurement. Conversely, graphical extrapolation from the passive expiration method (4) underestimated the elevation of FRC. In conclusion, we suggest using the mathematical extrapolation from the Brody's model to evaluate the elevation of FRC in mechanically ventilated infants: this method is non-invasive, does not require disruption of gas flow, can be easily performed with all the neonatal ventilators, and allows continuous breath-by-breath measurements.
Y Riou; L Storme; F Leclerc; V Neve; R Logier; P Lequien
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  25     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-05     Completed Date:  2000-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1118-25     Citation Subset:  IM    
Respiratory Physiology Department, Neonatal Medicine Department, Pediatric Intensive Care Department, Medical Technology Institute, CHRU de Lille, France.
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MeSH Terms
Airway Resistance
Blood Gas Analysis
Bronchiolitis / complications
Bronchopulmonary Dysplasia / complications
Functional Residual Capacity*
Hyaline Membrane Disease / complications
Infant, Newborn
Lung Compliance
Models, Statistical
Monitoring, Physiologic / methods*
Positive-Pressure Respiration, Intrinsic / diagnosis*,  etiology,  metabolism,  physiopathology
Reproducibility of Results
Respiration, Artificial / adverse effects,  methods*
Respiratory Insufficiency / etiology,  metabolism,  physiopathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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