| Comparison of four drugs for local treatment of burn wounds. | |
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MedLine Citation:
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PMID: 10340734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effective local treatment is very important in preventing wound infection and its generalization and ensuring successful skin grafting. The aim of our study is to compare the activity of four topical agents [deflamol (20 patients), polyvidone-iodine (21 patients), flammazine (silver sulphadiazine--SSD) (28 patients) and flammacerium (SSD with cerium nitrate) (five patients)] for treatment of patients with burns by confirming our clinical observations of their efficacy with comparative bacteriological investigations. The final estimation of our results showed the undoubted priority of flammazine and flammacerium over deflamol and polyvidone-iodine, as the treatment of all the patients with these two drugs gave very good and good results, respectively. In contrast, the results in 70% of the patients from the deflamol group and in 52.4% of those from the polyvidone-iodine group were unsatisfactory. At this stage we cannot find any significant differences in the antibacterial activity between flammazine and flammacerium. However, the excision of the firm eschars formed by flammacerium is easier and it gives the opportunity to postpone operation for a month or more. In conclusion we found suitable indications for preference of each of the topical agents included in our study. |
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Authors:
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O G Hadjiiski; M I Lesseva |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of emergency medicine : official journal of the European Society for Emergency Medicine Volume: 6 ISSN: 0969-9546 ISO Abbreviation: Eur J Emerg Med Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-07-19 Completed Date: 1999-07-19 Revised Date: 2010-07-22 |
Medline Journal Info:
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Nlm Unique ID: 9442482 Medline TA: Eur J Emerg Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 41-7 Citation Subset: IM |
Affiliation:
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Burns Section and Plastic Surgery Centre, Scientific Institute of Emergency Medicine N.I. Pirogov, Sofia, Bulgaria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adolescent Adult Aged Anti-Infective Agents, Local / pharmacology, therapeutic use* Bulgaria Burn Units Burns / diagnosis, drug therapy* Cerium / therapeutic use Child Child, Preschool Drug Combinations Female Follow-Up Studies Humans Infant Injury Severity Score Male Middle Aged Ointments / therapeutic use Povidone-Iodine / therapeutic use Silver Sulfadiazine / therapeutic use Treatment Outcome Wound Healing / drug effects Wound Infection / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Drug Combinations; 0/Ointments; 0/cerous nitrate, sulfadiazine silver drug combination; 22199-08-2/Silver Sulfadiazine; 25655-41-8/Povidone-Iodine; 7440-45-1/Cerium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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