| Comparison of flutamide and cyproterone acetate in the treatment of hirsutism: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 8701785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to compare the efficacy of flutamide and cyproterone acetate in the treatment of hirsutism. Twenty-two women with idiopathic hirsutism were randomized to receive either flutamide or cyproterone acetate. Each patient underwent a complete gynecological examination as well as an endocrinological profile and hematological, hepatic and renal function analyses. Hirsutism scores were determined using a modified Ferriman-Gallwey scoring system. These tests were then repeated at 3 and 9 months of therapy. Eleven patients received 250 mg of flutamide twice daily and 11 patients received 100 mg of cyproterone acetate on days 5-14 of the menstrual cycle. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. There was a trend towards a better response with flutamide, that did not achieve significance. Another significant difference was the increased sex hormone-binding globulin in both groups. A statistically significant decrease was also observed for the levels of testosterone on both drugs. No subject withdrew from the study due to a side-effect. The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamide is a safe, well-tolerated and effective alternative in treatment. |
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Authors:
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O Grigoriou; C Papadias; S Konidaris; G Antoniou; P Karakitsos; L Giannikos |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 10 ISSN: 0951-3590 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-09-05 Completed Date: 1996-09-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 119-23 Citation Subset: IM |
Affiliation:
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Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Androgen Antagonists / therapeutic use* Cyproterone / therapeutic use* Female Flutamide / therapeutic use* Hirsutism / drug therapy* Hormones / blood Humans Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 0/Hormones; 13311-84-7/Flutamide; 2098-66-0/Cyproterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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