| Comparison of fluorodeoxyglucose positron emission tomography and (111)indium-white blood cell imaging in the diagnosis of periprosthetic infection of the hip. | |
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MedLine Citation:
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PMID: 16950069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to compare the accuracy of fluorodeoxyglucose positron emission tomography (FDG-PET) with technetium-99m sulfur colloid (111)indium-labeled white blood cell scintigraphy (TcSC-Ind BM/WBC) in diagnosis of periprosthetic infection. Eighty-nine patients with 92 painful hip prostheses were recruited prospectively and given the option of undergoing either combined FDG-PET and TcSC-Ind BM/WBC or FDG-PET only. FDG-PET correctly diagnosed 20 of the 21 infected cases (sensitivity, 95.2%) and ruled out infection in 66 of the 71 aseptic hips (specificity, 93%) corresponding to a positive predictive value of 80% (20/25) and a negative predictive value of 98.5% (66/67). TcSC-Ind BM/WBC correctly identified 5 of the 10 infected cases (sensitivity, 50%) and 39 of 41 aseptic cases (specificity, 95.1%) corresponding to a positive and negative predictive values of 41.7% (5/12 cases) and 88.6% (39/44 cases), respectively. Based on these preliminary results, FDG-PET appears to be a promising diagnostic tool for distinguishing septic from aseptic painful hip prostheses. |
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Authors:
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Stephen G Pill; Javad Parvizi; Peter H Tang; Jonathan P Garino; Charles Nelson; Hongming Zhuang; Abass Alavi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of arthroplasty Volume: 21 ISSN: 0883-5403 ISO Abbreviation: J Arthroplasty Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-04 Completed Date: 2006-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703515 Medline TA: J Arthroplasty Country: United States |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Arthroplasty, Replacement, Hip / adverse effects* Biological Markers / blood Equipment Failure Analysis / methods Humans Indium / diagnostic use Leukocytes / radionuclide imaging* Middle Aged Pain Measurement Positron-Emission Tomography* Prospective Studies Prosthesis-Related Infections / radionuclide imaging* Radiopharmaceuticals / diagnostic use Reoperation Sensitivity and Specificity Technetium Tc 99m Sulfur Colloid / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Radiopharmaceuticals; 0/Technetium Tc 99m Sulfur Colloid; 10025-82-8/indium trichloride; 7440-74-6/Indium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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