| Comparison of findings on stress myocardial perfusion imaging in men with versus without erectile dysfunction and without prior heart disease. | |
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MedLine Citation:
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PMID: 18312766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Erectile dysfunction (ED) has been associated with a future risk of myocardial infarction, yet the findings on stress testing in men with ED and without previous coronary artery disease are unknown. Stress myocardial perfusion single-photon emission computed tomographic imaging (MPI) allows detection of coronary artery disease and predicts cardiovascular prognosis. Our goal was to determine the association between ED and findings at stress MPI testing in men without previous coronary artery disease. Five hundred seventy-five men without previous coronary artery disease referred for stress MPI were prospectively screened for ED with the validated International Index of Erectile Function. ED was present in 46% of subjects, and ED was associated with more mild (summed stress score >or=4) and severe (summed stress score >8) coronary artery disease and with more composite high-risk stress MPI findings (summed stress score >8, left ventricular ejection fraction <40%, transient ischemic dilation). In patients referred for exercise, ED was associated with a lower Duke treadmill score. On multivariate analysis, ED was found to be an independent predictor of a summed stress score >or=4, a summed stress score >8, and composite high-risk MPI findings. In conclusion, in men without known coronary artery disease referred for stress MPI testing, ED is associated with adverse prognostic indicators at MPI testing including coronary artery disease and high-risk MPI findings. |
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Authors:
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R Parker Ward; Justin Weiner; Linda A Taillon; S Nasir Ghani; James K Min; Kim A Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-26 |
Journal Detail:
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Title: The American journal of cardiology Volume: 101 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-03 Completed Date: 2008-03-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 502-5 Citation Subset: AIM; IM |
Affiliation:
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Section of Cardiology, Department of Medicine, University of Chicago Hospitals, Chicago, Illinois, USA. pward@medicine.bsd.uchicago.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Coronary Artery Disease / diagnosis Coronary Circulation* Diabetes Mellitus / epidemiology Erectile Dysfunction / epidemiology* Exercise Test* Heart / radionuclide imaging* Humans Male Middle Aged Multivariate Analysis Organophosphorus Compounds / diagnostic use Organotechnetium Compounds / diagnostic use Prospective Studies Radiopharmaceuticals / diagnostic use Severity of Illness Index Smoking / epidemiology Tomography, Emission-Computed, Single-Photon* Ventricular Dysfunction, Left / diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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