Document Detail

Comparison of findings on stress myocardial perfusion imaging in men with versus without erectile dysfunction and without prior heart disease.
MedLine Citation:
PMID:  18312766     Owner:  NLM     Status:  MEDLINE    
Erectile dysfunction (ED) has been associated with a future risk of myocardial infarction, yet the findings on stress testing in men with ED and without previous coronary artery disease are unknown. Stress myocardial perfusion single-photon emission computed tomographic imaging (MPI) allows detection of coronary artery disease and predicts cardiovascular prognosis. Our goal was to determine the association between ED and findings at stress MPI testing in men without previous coronary artery disease. Five hundred seventy-five men without previous coronary artery disease referred for stress MPI were prospectively screened for ED with the validated International Index of Erectile Function. ED was present in 46% of subjects, and ED was associated with more mild (summed stress score >or=4) and severe (summed stress score >8) coronary artery disease and with more composite high-risk stress MPI findings (summed stress score >8, left ventricular ejection fraction <40%, transient ischemic dilation). In patients referred for exercise, ED was associated with a lower Duke treadmill score. On multivariate analysis, ED was found to be an independent predictor of a summed stress score >or=4, a summed stress score >8, and composite high-risk MPI findings. In conclusion, in men without known coronary artery disease referred for stress MPI testing, ED is associated with adverse prognostic indicators at MPI testing including coronary artery disease and high-risk MPI findings.
R Parker Ward; Justin Weiner; Linda A Taillon; S Nasir Ghani; James K Min; Kim A Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-26
Journal Detail:
Title:  The American journal of cardiology     Volume:  101     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-03-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502-5     Citation Subset:  AIM; IM    
Section of Cardiology, Department of Medicine, University of Chicago Hospitals, Chicago, Illinois, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Coronary Artery Disease / diagnosis
Coronary Circulation*
Diabetes Mellitus / epidemiology
Erectile Dysfunction / epidemiology*
Exercise Test*
Heart / radionuclide imaging*
Middle Aged
Multivariate Analysis
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Prospective Studies
Radiopharmaceuticals / diagnostic use
Severity of Illness Index
Smoking / epidemiology
Tomography, Emission-Computed, Single-Photon*
Ventricular Dysfunction, Left / diagnosis
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

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