Document Detail


Comparison of fetal, newborn, and adult wound healing by histologic, enzyme-histochemical, and hydroxyproline determinations.
MedLine Citation:
PMID:  4045654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared simultaneous healing processes in fetal, newborn, and maternal rabbits using a miniaturized wound cylinder of expanded Gore-Tex tubing. The tubing was placed subcutaneously in fetal and maternal rabbits on day 23 of pregnancy (term = 31 to 32 days), and in 7-day-old newborn rabbits. At specific intervals, the tubing was removed and analyzed for hydroxyproline accumulation, histology, and cellular enzyme-histochemistry. Granulation tissue ingrowth and accumulation of hydroxyproline were each inversely related to age (fetus greater than newborn greater than maternal). The fetus showed an impressive infiltration of macrophages by day 4, fibroblasts by day 7, and a conspicuous lack of neutrophils in all specimens. Newborns and mothers had few cells until day 7, when a mixture of macrophages, neutrophils, and some fibroblasts appeared. We conclude that the fetus heals wounds rapidly by both mesenchymal cell proliferation and collagen deposition, and that these processes are more rapid in fetuses than in newborn or adult animals despite relative fetal hypoxemia.
Authors:
N S Adzick; M R Harrison; P L Glick; J H Beckstead; R L Villa; H Scheuenstuhl; W H Goodson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  20     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-11-12     Completed Date:  1985-11-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Animals, Newborn
Carboxylic Ester Hydrolases / analysis
Female
Fetus / physiology,  surgery*
Fibroblasts
Granulation Tissue
Hydroxyproline / analysis*
Macrophages
Naphthol AS D Esterase / analysis
Neutrophils
Rabbits
Reticulin / analysis
Wound Healing*
Grant Support
ID/Acronym/Agency:
AM 29890/AM/NIADDK NIH HHS; GM 27345/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Reticulin; 51-35-4/Hydroxyproline; EC 3.1.-/Naphthol AS D Esterase; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/chloroacetate esterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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