Document Detail

Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients.
MedLine Citation:
PMID:  18499399     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Postgastrectomy iron deficiency anemia has a variable prevalence and occurs in 20-50% of patients. Food fortification reports examining ferrous glycinate chelate have shown that it can be 2.5-3.4 times more bioavailable than ferrous sulfate, with minimal gastrointestinal symptoms. The present study was designed as a controlled experimental study including 18 gastrectomized patients with iron deficiency anemia to compare the effects of ferrous sulfate and ferrous glycinate chelate in the treatment of anemia and to evaluate the presence of side effects. METHODS: Patients were divided in two groups: group 1 received ferrous sulfate (200 mg twice a day, corresponding to 80 mg of elemental iron) and group 2 received ferrous glycinate chelate (250 mg/d, corresponding to 50 mg of elemental iron) for 4 mo. Laboratory measurements were performed at baseline and after 2 and 4 mo. RESULTS: Group 1 showed an apparent recovery in laboratory parameters, with increases in medium corpuscular hemoglobin (P = 0.02), serum iron (P = 0.02), and ferritin (P = 0.04), and a decrease in transferrin (P = 0.002) after 4 mo. Individualized analysis showed that only one patient using ferrous sulfate had anemia at the end of the study in contrast to six patients using ferrous glycinate. In addition, ferritin levels increased above 20 microg/L at the end of the study in seven patients using ferrous sulfate in contrast to one patient using ferrous glycinate. CONCLUSION: Patients with iron deficiency anemia after gastrectomy treated with ferrous sulfate had better results in hematologic laboratory parameters than those who used ferrous glycinate chelate.
Erika C Mayumi Mimura; José Wander Breganó; Jane Bandeira Dichi; Emerson Pereira Gregório; Isaias Dichi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-05-21
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  24     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  663-8     Citation Subset:  IM    
Cancer Hospital of Londrina, Londrina, Paraná, Brazil.
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MeSH Terms
Anemia, Iron-Deficiency / drug therapy*
Biological Availability
Ferritins / blood
Ferrous Compounds / pharmacokinetics*,  therapeutic use
Gastrectomy / adverse effects*
Glycine / analogs & derivatives*,  pharmacokinetics,  therapeutic use
Hemoglobins / metabolism
Intestinal Absorption
Iron / blood
Iron Chelating Agents / pharmacokinetics*,  therapeutic use
Middle Aged
Nutritional Status
Treatment Outcome
Reg. No./Substance:
0/Ferrous Compounds; 0/Hemoglobins; 0/Iron Chelating Agents; 0/bis-glycino iron II; 56-40-6/Glycine; 7439-89-6/Iron; 7720-78-7/ferrous sulfate; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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