Document Detail


Comparison of fecal microflora in children with atopic eczema/dermatitis syndrome according to IgE sensitization to food.
MedLine Citation:
PMID:  16618364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atopic eczema/dermatitis syndrome (AEDS) commonly often arises during early infancy. In several intervention studies a beneficial influence on AEDS course of certain intestinal bacteria, administered as 'probiotics', has been described. To evaluate the possible role of the natural intestinal microflora in children with allergic eczema/dermatitis syndrome regarding immediate type hypersensitivity to food allergens, children with food allergy (AAEDS, n = 68) have been compared with children without detectable food allergy (NAEDS, n = 25). All children (n = 93) in preschool age, mean age of 2.6 (+/-1.8) years, diagnosed with AEDS who were treated as inpatients in 2003 in a dermatological hospital were included. The correlation between fecal microflora, parasites and specific immunoglobulin E (IgE) antibodies against common food allergens was analyzed. A similar composition of intestinal microflora in children with AAEDS and NAAEDS was found. The food allergens that were most frequently detected were egg white, cow milk, casein, peanut and hazelnut. Furthermore, a significant association between IgE sensitization against important food allergens and components of the fecal microflora could not be demonstrated. With aging changes occur in the intestinal microbiota [Proteus/Klebsiella and age (rho = -0.607) and Enterococcus and age (rho = -0.428)]. In two subjects of the AAEDS group Blastocystis hominis was found. The composition of natural intestinal microflora in children with AAEDS and NAAEDS was similar. Hence, there is no evidence of a role of the intestinal microflora with regard to the development of infant (food) allergy in children with AEDS. The possible consequences for allergic diseases later in life require further investigation.
Authors:
Michael Kendler; Wolfgang Uter; Andreas Rueffer; Raffael Shimshoni; Eckehardt Jecht
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  17     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2007-03-26     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Affiliation:
Hospital of Dermatology, Schloss Friedensburg, Leutenberg, Germany. mi.ke@gmx.at
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MeSH Terms
Descriptor/Qualifier:
Antibody Specificity / immunology
Bacteria / isolation & purification
Candida / isolation & purification
Child
Dermatitis, Atopic / immunology,  microbiology*,  parasitology
Feces / microbiology*,  parasitology
Female
Food Hypersensitivity / immunology,  microbiology*,  parasitology
Humans
Immunoglobulin E / immunology*
Infant
Intestines / parasitology
Male
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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