Document Detail


Comparison of the fatal toxicity index of zopiclone with benzodiazepines.
MedLine Citation:
PMID:  14705844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Zopiclone is a hypnosedative structurally unrelated to the benzodiazepines but operating at the same receptor complex. Although zopiclone has been used in clinical practice for many years, relatively little is known of its relative toxicity in comparison with other hypnosedatives. METHOD: Deaths, where hypnosedatives were implicated, in New Zealand (NZ) in 2001 were identified from a chemical injury database. Prescription and aggregate defined daily dose (DDD) data forNZ in 2001 were obtained from a national prescribing database. Rates of death per prescription and DDD, and relative rates between individual hypnosedatives and benzodiazepines, and their respective 95% CI were calculated. RESULTS: Of the 200 poisoning deaths in NZ for 2001, 39 involved hypnosedatives, and zopiclone was involved in 12. Hypnosedatives were the sole agents in only one death and were the primary agents in eight deaths. Zopiclone was the sixth most commonly involved agent in poisoning deaths in NZ in 2001. The relative rate of death per prescription (95% CI) and DDD (95% CI) of zopiclone compared with benzodiazepines were 1.04 (0.49-2.05) and 0.59 (0.28-1.16), respectively. The relative rates of death per DDD (95% CI) for alprazolam and chlormethiazole compared with the other sedatives/anxiolytics were 6.2 (1.6-17.0) and 20.9 (2.5-79.8) respectively. CONCLUSIONS: The fatal toxicity for zopiclone was not significantly different from that for benzodiazepines as a group when adjusted for usage, whereas alprazolam and chlormethiazole had greater toxicity. Hypnosedatives are contributory factors rather than primary substances in poisoning deaths.
Authors:
David M Reith; John Fountain; Rebecca McDowell; Murray Tilyard
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  41     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  2003  
Date Detail:
Created Date:  2004-01-06     Completed Date:  2004-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  975-80     Citation Subset:  AIM; IM    
Affiliation:
Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. david.reith@stonebow.otago.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Azabicyclo Compounds
Benzodiazepines / administration & dosage,  poisoning*
Child
Child, Preschool
Databases, Factual
Drug Prescriptions
Humans
Hypnotics and Sedatives / administration & dosage,  poisoning*
Middle Aged
New Zealand / epidemiology
Piperazines / administration & dosage,  poisoning*
Poisoning / etiology,  mortality*
Chemical
Reg. No./Substance:
0/Azabicyclo Compounds; 0/Hypnotics and Sedatives; 0/Piperazines; 12794-10-4/Benzodiazepines; 43200-80-2/zopiclone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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