Document Detail


Comparison of fascin expression in anaplastic large cell lymphoma and Hodgkin disease.
MedLine Citation:
PMID:  12579989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diagnostic difficulties sometimes arise in distinguishing anaplastic large cell lymphoma (ALCL) from Hodgkin disease (HD), especially the syncytial variant. Study of the biologic features of diagnostic Reed-Sternberg cells in HD, in search of specific markers for Reed-Sternberg cells, has suggested fascin as a relatively specific and sensitive marker. We studied the frequency of fascin expression in 30 ALCLs and 34 cases of classic HD, including 17 cases of the syncytial variant. Staining with CD30 and anaplastic lymphoma kinase (ALK)-1 also was performed in all cases. All ALCL and HD cases showed membranous and Golgi zone CD30 positivity. Fascin stained all HD cases but also stained 67% (20/30) of the ALCLs in a cytoplasmic pattern. Fascin positivity was observed in 59% (10/17) of T-cell ALCLs and 77% (10/13) of null-cell ALCLs; ALK-1-positive ALCLs, regardless of origin, were usually fascin-positive (91% [10/11]). In conclusion, fascin shows strong positivity in all cases of classic HD but also is positive in the majority of ALCLs, including ALK-1-positive and ALK-1-negative cases. Positive staining for fascin is not useful for distinguishing ALCL from HD. In some cases, fascin negativity may help rule out classic HD.
Authors:
Guang Fan; Patricia Kotylo; Richard S Neiman; Rita M Braziel
Related Documents :
14708739 - Primary ocular adnexal lymphoma in pediatric patients: report of two cases and review o...
12528279 - A case of visceral leishmaniasis in the northern adriatic region.
7662979 - Analysis of the t(2;5)(p23;q35) translocation by reverse transcription-polymerase chain...
12962439 - Benign nodular lymphoid hyperplasia of colon: a report of two cases.
11444509 - Non-hodgkin's lymphoma involving the gynecologic tract: a review of 88 cases.
1745569 - Ovarian follicular non-hodgkins lymphoma.
8304759 - Bowen's disease of the nail bed and periungual area. a clinicopathologic analysis of se...
23661959 - Brachial plexus injury in adults: diagnosis and surgical treatment strategies.
16767559 - A case of systemic sclerosis complicated by idiopathic portal hypertension: case report...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  119     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-02-26     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code L471, Portland, OR 97201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Actins / metabolism*
Adolescent
Adult
Age Distribution
Aged
Carrier Proteins / metabolism*
Child
DNA, Neoplasm / analysis
Diagnosis, Differential
Female
Hodgkin Disease / metabolism*,  pathology
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Infant, Newborn
Lymph Nodes / metabolism,  pathology
Lymphoma, Large-Cell, Anaplastic / metabolism*,  pathology
Male
Microfilament Proteins / metabolism*
Middle Aged
Protein-Tyrosine Kinases / metabolism
Reed-Sternberg Cells
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Actins; 0/Carrier Proteins; 0/DNA, Neoplasm; 0/Microfilament Proteins; 0/Tumor Markers, Biological; 146808-54-0/fascin; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/anaplastic lymphoma kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nodular lymphocyte predominant Hodgkin lymphoma. An immunophenotypic reappraisal based on a single-i...
Next Document:  Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry.