Document Detail

Comparison of fascin expression in anaplastic large cell lymphoma and Hodgkin disease.
MedLine Citation:
PMID:  12579989     Owner:  NLM     Status:  MEDLINE    
Diagnostic difficulties sometimes arise in distinguishing anaplastic large cell lymphoma (ALCL) from Hodgkin disease (HD), especially the syncytial variant. Study of the biologic features of diagnostic Reed-Sternberg cells in HD, in search of specific markers for Reed-Sternberg cells, has suggested fascin as a relatively specific and sensitive marker. We studied the frequency of fascin expression in 30 ALCLs and 34 cases of classic HD, including 17 cases of the syncytial variant. Staining with CD30 and anaplastic lymphoma kinase (ALK)-1 also was performed in all cases. All ALCL and HD cases showed membranous and Golgi zone CD30 positivity. Fascin stained all HD cases but also stained 67% (20/30) of the ALCLs in a cytoplasmic pattern. Fascin positivity was observed in 59% (10/17) of T-cell ALCLs and 77% (10/13) of null-cell ALCLs; ALK-1-positive ALCLs, regardless of origin, were usually fascin-positive (91% [10/11]). In conclusion, fascin shows strong positivity in all cases of classic HD but also is positive in the majority of ALCLs, including ALK-1-positive and ALK-1-negative cases. Positive staining for fascin is not useful for distinguishing ALCL from HD. In some cases, fascin negativity may help rule out classic HD.
Guang Fan; Patricia Kotylo; Richard S Neiman; Rita M Braziel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  119     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-02-26     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  AIM; IM    
Department of Pathology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code L471, Portland, OR 97201, USA.
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MeSH Terms
Actins / metabolism*
Age Distribution
Carrier Proteins / metabolism*
DNA, Neoplasm / analysis
Diagnosis, Differential
Hodgkin Disease / metabolism*,  pathology
In Situ Hybridization, Fluorescence
Infant, Newborn
Lymph Nodes / metabolism,  pathology
Lymphoma, Large-Cell, Anaplastic / metabolism*,  pathology
Microfilament Proteins / metabolism*
Middle Aged
Protein-Tyrosine Kinases / metabolism
Reed-Sternberg Cells
Tumor Markers, Biological
Reg. No./Substance:
0/Actins; 0/Carrier Proteins; 0/DNA, Neoplasm; 0/Microfilament Proteins; 0/Tumor Markers, Biological; 146808-54-0/fascin; EC Kinases; EC lymphoma kinase

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