| Comparison of fascin expression in anaplastic large cell lymphoma and Hodgkin disease. | |
| | |
MedLine Citation:
|
PMID: 12579989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Diagnostic difficulties sometimes arise in distinguishing anaplastic large cell lymphoma (ALCL) from Hodgkin disease (HD), especially the syncytial variant. Study of the biologic features of diagnostic Reed-Sternberg cells in HD, in search of specific markers for Reed-Sternberg cells, has suggested fascin as a relatively specific and sensitive marker. We studied the frequency of fascin expression in 30 ALCLs and 34 cases of classic HD, including 17 cases of the syncytial variant. Staining with CD30 and anaplastic lymphoma kinase (ALK)-1 also was performed in all cases. All ALCL and HD cases showed membranous and Golgi zone CD30 positivity. Fascin stained all HD cases but also stained 67% (20/30) of the ALCLs in a cytoplasmic pattern. Fascin positivity was observed in 59% (10/17) of T-cell ALCLs and 77% (10/13) of null-cell ALCLs; ALK-1-positive ALCLs, regardless of origin, were usually fascin-positive (91% [10/11]). In conclusion, fascin shows strong positivity in all cases of classic HD but also is positive in the majority of ALCLs, including ALK-1-positive and ALK-1-negative cases. Positive staining for fascin is not useful for distinguishing ALCL from HD. In some cases, fascin negativity may help rule out classic HD. |
| | |
Authors:
|
Guang Fan; Patricia Kotylo; Richard S Neiman; Rita M Braziel |
Related Documents
:
|
14708739 - Primary ocular adnexal lymphoma in pediatric patients: report of two cases and review o... 12528279 - A case of visceral leishmaniasis in the northern adriatic region. 7662979 - Analysis of the t(2;5)(p23;q35) translocation by reverse transcription-polymerase chain... 12962439 - Benign nodular lymphoid hyperplasia of colon: a report of two cases. 11444509 - Non-hodgkin's lymphoma involving the gynecologic tract: a review of 88 cases. 1745569 - Ovarian follicular non-hodgkins lymphoma. 8304759 - Bowen's disease of the nail bed and periungual area. a clinicopathologic analysis of se... 23661959 - Brachial plexus injury in adults: diagnosis and surgical treatment strategies. 16767559 - A case of systemic sclerosis complicated by idiopathic portal hypertension: case report... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: American journal of clinical pathology Volume: 119 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-02-12 Completed Date: 2003-02-26 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 199-204 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code L471, Portland, OR 97201, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Actins
/
metabolism* Adolescent Adult Age Distribution Aged Carrier Proteins / metabolism* Child DNA, Neoplasm / analysis Diagnosis, Differential Female Hodgkin Disease / metabolism*, pathology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Infant, Newborn Lymph Nodes / metabolism, pathology Lymphoma, Large-Cell, Anaplastic / metabolism*, pathology Male Microfilament Proteins / metabolism* Middle Aged Protein-Tyrosine Kinases / metabolism Reed-Sternberg Cells Tumor Markers, Biological |
| Chemical | |
Reg. No./Substance:
|
0/Actins; 0/Carrier Proteins; 0/DNA, Neoplasm; 0/Microfilament Proteins; 0/Tumor Markers, Biological; 146808-54-0/fascin; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.1/anaplastic lymphoma kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nodular lymphocyte predominant Hodgkin lymphoma. An immunophenotypic reappraisal based on a single-i...
Next Document: Immunophenotypic analysis of anaplastic large cell lymphoma by flow cytometry.