Document Detail


Comparison of extracorporal shock wave pretreatment to classic surgical delay in a random pattern skin flap model.
MedLine Citation:
PMID:  21532412     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: : Extracorporal shock wave therapy has a significant positive effect on rescuing the ischemic zone of flap tissue if applied immediately after surgical intervention. The purpose of this study was to determine the potential preoperative effect of noninvasive extracorporal shock wave therapy to precondition flap tissue compared with the well-established surgical delay procedure.
METHODS: : Thirty-two male Wistar rats were randomized into four groups, and an oversized, random-pattern flap was raised in each animal. In group D7, a surgical delay was carried out 1 week before full flap harvest. In group E7, the whole flap area was treated with extracorporal shock wave therapy to induce mechanical delay. Group E7D7 was treated preoperatively with a combination of surgical delay and extracorporal shock wave therapy. Group C constituted the control group, in which the skin flap was harvested without any prior intervention. Seven days after flap harvest, flap survival, perfusion, microvessel density, and vascular endothelial growth factor concentration were assessed.
RESULTS: : Flap survival, perfusion, and microvessel density were significantly increased in the delay group (group D7) and the extracorporal shock wave therapy group (group E7) compared with the control group (group C). Combining both pretreatments (group E7D7) did not have a favorable cumulative effect. Vascular endothelial growth factor expression was not significantly increased in any group.
CONCLUSIONS: : Although not superior to surgical delay, the authors see many advantages of extracorporal shock wave therapy; it is noninvasive, easily applicable, less time- consuming, and less expensive. Thus, it may constitute an alternative procedure in clinical situations that warrant a noninvasive, fast, and easily applicable treatment.
Authors:
Matthias Artur Reichenberger; Holger Keil; Wolf Mueller; Christel Herold-Mende; Martha Maria Gebhard; Günter Germann; Holger Engel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  127     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1830-7     Citation Subset:  AIM; IM    
Affiliation:
Ludwigshafen and Heidelberg, Germany From the Department of Plastic and Hand Surgery, Burn Center, BG Trauma Center, Ludwigshafen; and Plastic and Hand Surgery, the Department of Neuropathology at the Institute for Pathology, the Division of Neurosurgical Research, Department of Neurosurgery, and the Department of Experimental Surgery, University of Heidelberg.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of rapamycin thera...
Next Document:  Colistin-Loaded Silk Membranes against Wound Infection with Pseudomonas aeruginosa.