| Comparison of extracellular dopamine concentration in awake unstressed and postsurgical nitrous oxide sedated rats. | |
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MedLine Citation:
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PMID: 8563449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrous oxide (N2O), 70%, in O2 is often used as a control condition after surgical preparation in rodents undergoing neuroscience investigations. Concern has been expressed that this constitutes a stressful condition. Microdialysis was used in 15 rats to assess extracellular striatal dopamine concentrations during overnight soundproof isolation and on the following day after vascular cannulation and halothane excretion under N2O sedation with concomitant neuromuscular blockade. The overnight dialysate dopamine concentration was 22.8 +/- 8.7 pg/40 microliters. Thirty minutes after stopping halothane, the dialysate concentration was 362.6 +/- 91.6 pg/40 microliters during postsurgical N2O sedation. These data indicate that (a) compared to an unstressed baseline, significant brain dopamine effects occur with N2O sedation after surgery with halothane N2O anesthesia, and (b) baseline conditions can have a major effect on microdialysis data expressed as percentage of baseline. |
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Authors:
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W A Kofke; R L Stiller; M E Rose |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neurosurgical anesthesiology Volume: 7 ISSN: 0898-4921 ISO Abbreviation: J Neurosurg Anesthesiol Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-03-01 Completed Date: 1996-03-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8910749 Medline TA: J Neurosurg Anesthesiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 280-3 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology/CCM and Neurologic Surgery, University of Pittsburgh, Pennsylvania 15261, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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pharmacology* Animals Blood Glucose / metabolism Dopamine / metabolism* Extracellular Space / drug effects, metabolism* Hypnotics and Sedatives / pharmacology* Male Microdialysis Neostriatum / drug effects, metabolism Nerve Block Nitrous Oxide / pharmacology* Postoperative Period Rats Rats, Sprague-Dawley Respiration, Artificial Stress, Physiological / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Blood Glucose; 0/Hypnotics and Sedatives; 10024-97-2/Nitrous Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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