Document Detail

Comparison of the expression of Langerin and 175 kD mannose receptor in antigen-presenting cells in normal human skin and basal cell carcinoma.
MedLine Citation:
PMID:  15222130     Owner:  NLM     Status:  MEDLINE    
The presence of professional antigen-presenting cells in tumours can influence their further spreading. Location of cells exhibiting a specific marker of Langerhans cells--Langerin, and the 175 kD mannose receptor as a marker of dendritic cells of non-Langerhans type and macrophages, was studied using double staining in the normal human epidermis and in basal cell carcinomas. The Langerin-positive cells strictly colonized the epidermis and no cells were found in the dermis, where 175 kD mannose receptor-exhibiting cells were present. Very rare elements in the epidermal/dermal interface were positive for both markers. A low incidence of Langerin-positive cells was found in tumours and 1/3 of studied carcinomas were even Langerhans cell-free. The extraepithelial presence of Langerin-positive cells forming contacts with dendrite-like protrusions of 175 kD mannose receptor-exhibiting cells was found in connective tissue surrounding the tumour epithelium and indicates possible cooperation of both elements.
Z Plzáková; M Chovanec; K Smetana; J Plzák; J Stork; S Saeland
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia biologica     Volume:  50     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-29     Completed Date:  2005-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  IM    
Charles University, 1st Faculty of Medicine, Institute of Anatomy, Prague, Czech Republic.
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MeSH Terms
Antigen-Presenting Cells / metabolism*
Antigens, CD
Antigens, Surface / metabolism*
Carcinoma, Basal Cell / metabolism*
Dermis / metabolism
Epidermis / metabolism
Langerhans Cells / metabolism
Lectins, C-Type / metabolism*
Mannose-Binding Lectins / metabolism*
Receptors, Cell Surface / metabolism*
Skin / metabolism*
Skin Neoplasms / metabolism*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Surface; 0/CD207 protein, human; 0/Lectins, C-Type; 0/Mannose-Binding Lectins; 0/Receptors, Cell Surface; 0/mannose receptor

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