| Comparison of exhaled nitric oxide measurements between NIOX MINO electrochemical and Ecomedics chemiluminescence analyzer. | |
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MedLine Citation:
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PMID: 18694637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Exhaled nitric oxide (eNO) is an established, noninvasive biomarker of active airway inflammation in (atopic) asthma. Treatment with anti-inflammatory therapy, such as inhaled corticosteroids, effectively decreases eNO levels. The NIOX MINO (MINO) is a hand-held, relatively inexpensive, electrochemical device that has been shown to yield comparable eNO measurements to the NIOX stationary unit. AIM: To compare measurements of MINO with another widely used and validated stationary chemiluminescence analyzer, the Ecomedics (ECO). METHODS: We performed subsequent eNO measurements on ECO and MINO in 50 subjects (19 healthy volunteers, 18 healthy smokers and 13 non-smoking, atopic asthmatics, not on controller therapy) on two visits 4-10 days apart. The mean of three acceptable measurements by ECO and the first acceptable measurement with the MINO were used for analysis. RESULTS: Both devices yielded reproducible eNO values for all subjects on both visits, with an overall CV of 22.7% (ECO) and 18.3% (MINO). A significant correlation was found between both devices (r=0.97, p<0.0001). Bland-Altman plots showed a high degree of agreement for the entire study population (mean difference MINO vs ECO=-10%; 95% limit of agreement were -36% and +28%) and in the three individual subgroups. CONCLUSIONS: Exhaled NO values measured with the MINO are reproducible and in agreement with the ECO. Our results add further evidence to the reliability of the MINO and warrant its applicability in research and clinical practice. |
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Authors:
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J D Boot; L de Ridder; M L de Kam; C Calderon; M A Mascelli; Z Diamant |
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Publication Detail:
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Type: Comparative Study; Journal Article; Validation Studies Date: 2008-08-10 |
Journal Detail:
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Title: Respiratory medicine Volume: 102 ISSN: 1532-3064 ISO Abbreviation: Respir Med Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 1667-71 Citation Subset: IM |
Affiliation:
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Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands. dboot@chdr.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / metabolism*, physiopathology Biological Markers / analysis Breath Tests / instrumentation Chemiluminescent Measurements / instrumentation*, methods Electrochemistry Equipment Design Exhalation / physiology Female Humans Male Middle Aged Nitric Oxide / analysis* Patient Selection Practice Guidelines as Topic Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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