| Comparison of exercise electrocardiography and dobutamine echocardiography. | |
| | |
MedLine Citation:
|
PMID: 1395198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is uncertain whether dobutamine echocardiography is a better test than exercise electrocardiography for the detection of coronary disease in patients who can exercise. We compared the hemodynamics, sensitivity, and specificity of these tests in 24 patients, 16 with coronary disease and 8 controls. The tests were performed within six weeks of one another and were interpreted without knowledge of other clinical data. The exercise electrocardiogram was considered abnormal if the patient developed one mm of ST-segment depression, while the dobutamine test (up to 40 micrograms/kg/min) was considered abnormal if the patient developed ST-segment depression or a left ventricular wall motion abnormality. Exercise testing resulted in a higher heart rate (145 +/- 29 vs. 110 +/- 24, p less than 0.001) and blood pressure (176 +/- 31 vs. 148 +/- 24, p less than 0.001). Dobutamine testing was 25% more sensitive than exercise testing (94 vs. 69%, 95% confidence interval for difference is 0 to 50%, p = 0.09), while exercise testing was 38% more specific (88 vs. 50%, 95% confidence interval for difference is -3 to 79%, p = 0.14). We conclude that exercise results in a higher heart rate and blood pressure than dobutamine infusion. Differences in sensitivity and specificity are inconclusive, but indicate that the sensitivity of exercise testing is, at best, equivalent to dobutamine testing, while any increase in specificity with dobutamine testing, compared with exercise testing, would not be clinically significant. |
| | |
Authors:
|
T W Martin; J F Seaworth; J P Johns |
Related Documents
:
|
2604918 - Acute effects of carbon monoxide exposure on individuals with coronary artery disease. 3115078 - Ambulatory monitoring of the digitized electrocardiogram for detection and early warnin... 8070478 - Arrhythmias and st segment deviation during prolonged exhaustive exercise (ski marathon... 8916478 - Accurate detection of coronary artery disease by integrated analysis of the st-segment ... 11842038 - Effect of exercise intensity on 24-h energy expenditure and nutrient oxidation. 3768778 - Comparison of fick and dye cardiac outputs during rest and exercise in 1,022 patients. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Review |
Journal Detail:
|
Title: Clinical cardiology Volume: 15 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1992 Sep |
Date Detail:
|
Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 641-6 Citation Subset: IM |
Affiliation:
|
Cardiology Service, Brooke Army Medical Center, Fort Sam Houston, Texas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Blood Pressure Coronary Angiography Coronary Disease / diagnosis*, physiopathology Dobutamine / diagnostic use* Echocardiography / methods* Electrocardiography* Exercise Test* Female Heart Rate Humans Male Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The prevention of atherosclerosis with antioxidants.
Next Document: A "lipo-protective" effect of a fixed combination of captopril and hydrochlorothiazide in antihypert...