| Comparison of evening and morning dosing of travoprost 0.004%/timolol 0.5% fixed combination in 6 month period. | |
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MedLine Citation:
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PMID: 20977071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An open label, multi-center, 6 months observational study of new fixed combination (travoprost 0.004%/timolol 0.5%), in order to evaluate both efficacy (intraocular pressure lowering) and tolerability (patient and investigator satisfaction) of two dosing regimens--evening (PM) and morning (AM). After screening for enrollment, to 40 patients (79 eyes with primary open angle glaucoma or ocular hypertension), new fixed combination travoprost 0.004%/timolol 0.5% was prescribed once a day in the evening (PM). Patients were enrolled according to each investigator decision on indication for travoprost 0.004%/timolol 0.5% fixed combination once a day, without washout period after previous medication. Intraocular pressure was measured at 9 AM at all time control points: at baseline, after 1 month, after 3 months and after 6 month. After 1 month, screening for nonresponders (criteria: 20% intraocular pressure lowering) and subjects with major side effects was performed. At second control visit, after 3 months PM dosing, intraocular pressure was measured and patients were instructed to continue once a day the same medication, but in the morning (AM) for consequent 3 months. After 1 month, reduction in mean intraocular pressure value was 21.66%. At the visit after 3 month, the mean intraocular pressure was 15.67 +/- 2.17 mm Hg (reduction 21.14%). 3 month after dosing regimen changed to AM (6 month after beginning of travoprost 0.004%/timolol 0.5% combination therapy), reduction in intraocular pressure value was 19.86%. The differences (mean +/- standard deviation) in intraocular pressure values after 1, 3 and 6 month were all highly statistically significant compared to baseline values. The tolerability was evaluated in five steps (Likert scale) ranging from unsatisfactory to excellent by both patient and investigator--taken at 3 and 6 month control visit. 95% of patients and 100% of investigators were satisfied with the possibility of choosing dosing regimen for travoprost 0.004%/timolol 0.5% fixed combination. Travoprost 0.004%/timolol 0.5% fixed combination proved sufficient intraocular pressure control dosed either PM or AM with no statistically significant difference between two dosing regimens. Possibility to choose between two dosing regimens gives each practitioner additional reassurance that glaucoma therapy will be individualised to needs of each patient. |
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Authors:
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Smiljka Popović Suić; Katia Novak Laus; Vukosava Maricic Dosen; Miroslav Ekert; Zdravko Mandić; Lovro Bojić |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Collegium antropologicum Volume: 34 ISSN: 0350-6134 ISO Abbreviation: Coll Antropol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003354 Medline TA: Coll Antropol Country: Croatia |
Other Details:
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Languages: eng Pagination: 847-52 Citation Subset: IM |
Affiliation:
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Department of Ophtalmology, Zagreb University Hospital Center, Zagreb, Croatia. spopovic@kbc-zagreb.hr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cloprostenol
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administration & dosage,
adverse effects,
analogs & derivatives* Drug Combinations Female Glaucoma, Open-Angle / drug therapy*, physiopathology Humans Intraocular Pressure / drug effects Male Prospective Studies Timolol / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 157283-68-6/travoprost; 26839-75-8/Timolol; 40665-92-7/Cloprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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