Document Detail

Comparison of estimated daily intakes of flavouring substances with no-observed-effect levels.
MedLine Citation:
PMID:  16325977     Owner:  NLM     Status:  MEDLINE    
This study was conducted to determine the margins of safety between no-observed-effect levels (NOELs) and estimates of daily intake for 809 flavouring substances evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) between 2000 and 2004. Estimates of daily intake were calculated using two methods, the maximized survey-derived daily intake (MSDI) and the possible average daily intake (PADI). The MSDI estimates were based on the production volume of flavouring agents as reported by industry, whereas the higher more conservative PADI estimates were derived by multiplying the anticipated average use level of a flavouring substance in each of 33 food categories by the average amount of food consumed daily from that food category and summing the intake over all 33 food categories. These intake estimates were used to calculate the margins of safety for the flavouring agents to determine whether adequate margins of safety would still exist in the event that the MSDIs used by JECFA to evaluate the safety of flavouring substances underestimated daily intakes. Based on the calculation of the margins of safety using the MSDI values, 99.9% of the 809 flavouring substances evaluated by JECFA have margins of safety of greater than 100. In comparison, 98% of flavouring substances have margins of safety of greater than 100 when the margins of safety were calculated from PADI values. The results indicate that if the MSDI estimates used by JECFA for the evaluation of the safety of flavouring substances were underestimated, a wide margin of safety exists for all but a few of the flavouring substances even when intakes were estimated from PADI values.
I C Munro; B Danielewska-Nikiel
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-12-01
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  44     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-04-05     Completed Date:  2006-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  758-809     Citation Subset:  IM    
CANTOX Health Sciences International, Mississauga, Ont., Canada L5N 2X7.
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MeSH Terms
Alcohols / administration & dosage
Aldehydes / administration & dosage
Dose-Response Relationship, Drug
Esters / administration & dosage
Evaluation Studies as Topic
Flavoring Agents / administration & dosage*,  adverse effects
Furans / administration & dosage
Hydrocarbons, Aromatic / administration & dosage
Ketones / administration & dosage
Monoterpenes / administration & dosage
Phenol / administration & dosage
Propanols / administration & dosage
Pyrazines / administration & dosage
Reg. No./Substance:
0/Alcohols; 0/Aldehydes; 0/Esters; 0/Flavoring Agents; 0/Furans; 0/Hydrocarbons, Aromatic; 0/Ketones; 0/Monoterpenes; 0/Propanols; 0/Pyrazines; 104-54-1/cinnamyl alcohol; 108-95-2/Phenol; 15932-80-6/pulegone; 98-00-0/furfuryl alcohol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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