Document Detail

Comparison of the erythrocyte sedimentation rate measured in the eye casualty department by the Seditainer method with an automated system.
MedLine Citation:
PMID:  10707139     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare a new automated system for the measurement of erythrocyte sedimentation rate (ESR) with the established manual Seditainer method. METHODS: Two hundred and twelve patients undergoing investigation for giant cell arteritis or other systemic vasculitides had ESR measurements by both the established manual Seditainer and the new laboratory-based automated system. The results were compared by correlation coefficient and mean difference. The limits of agreement with confidence intervals were also calculated. RESULTS: Across the range of results from 1 to 120 mm/h, the correlation coefficient was 0.844. The automated method had a mean negative bias of -9.8 mm/h (95% confidence interval: -12.2 to -7.4 mm/h). The wide scatter of results produced limits of agreement (+/- 2 standard deviations) between the two methods of -45 to 26 mm/h. There were seven results that were underestimated by the automated system which were clinically significant. CONCLUSIONS: There is a wide degree of scatter between the two sets of results. The automated system has a negative bias when compared with the manual method. There is a propensity for the automated system to sporadically underestimate the true result, sometimes to a degree that is clinically significant. The authors therefore cannot recommend replacement of the manual Seditainer system at the present time.
A C Browning; A A Burbidge; P R Hodgkins
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Eye (London, England)     Volume:  13 ( Pt 6)     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-04-04     Completed Date:  2000-04-04     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  754-7     Citation Subset:  IM    
Southampton Eye Unit, Southampton General Hospital, UK.
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MeSH Terms
Aged, 80 and over
Blood Sedimentation*
Emergency Service, Hospital
Giant Cell Arteritis / blood*,  diagnosis
Middle Aged
Point-of-Care Systems

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