Document Detail

Comparison of equations to estimate the glomerular filtration in people aged 75 or older without known renal disease
MedLine Citation:
PMID:  20022063     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: To compare the glomerular filtration rate (GFR) of patients aged 75 and older without known renal disease estimated by the MDRD-4-IDMS (MDRD) formula, urine 24h creatinine clearance (24h-CC) and Cockroft-Gault (CG) formula. PATIENTS AND METHODS: There were included 70 persons aged 75 and older from the geriatric external consultation. We compared the MDRD against the CG and the 24h-CC. RESULTS: Means of GFR were: 24h-CC: 56,60 + or - 22,79 ml/min/1.73 m(2) and CG: 54,27 + or - 15,25 ml/min/1.73 m(2), significantly lower than with MDRD: 69,78 + or - 18,53 ml/min/1.73 m(2) (p<0.001). Age was correlated with the difference between CG and MDRD (coefficient of correlation: 0,59; r(2):0,34; p<0,001). Moderate agreement was obtained between MDRD with CG (k coefficient = 0.37; CI95%=0.19-0.55) and MDRD with 24-CC (k coefficient = 0.39; CI95% = 0.22-0.57). CONCLUSIONS: The MDRD and CG formulas to estimate the FGR in people aged 75 and older are not interchangeable. There are needed specific studies in old people to establish the most precise formula.
Javier Gómez-Pavón; César Gálvez Barrón; Juan José Baztán Cortés; Isidoro Ruipérez Cantera
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Medicina clínica     Volume:  134     ISSN:  0025-7753     ISO Abbreviation:  Med Clin (Barc)     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376377     Medline TA:  Med Clin (Barc)     Country:  Spain    
Other Details:
Languages:  spa     Pagination:  346-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier España, S.L. All rights reserved.
Servicio de Geriatría, Hospital Central de la Cruz Roja, Madrid, España.
Vernacular Title:
Comparación del uso de las ecuaciones de estimación del filtrado glomerular renal en personas de 75 años o más sin enfermedad renal conocida.
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MeSH Terms
Aged, 80 and over
Creatine / urine
Glomerular Filtration Rate*
Reg. No./Substance:

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