| Comparison of enprostil and cimetidine in active duodenal ulcer disease. Summary of pooled European studies. | |
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MedLine Citation:
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PMID: 3092659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data were combined for statistical analysis from four European trials comparing enprostil (35 micrograms twice daily) with cimetidine (400 mg twice daily) in the treatment of duodenal ulcer, using a double-blind, randomized design with endoscopic control. A total of 369 patients entered the trials, of whom 348 were eligible for the efficacy analyses and 362 for the safety analyses. Patients were allowed antacids as needed. The pooled cumulative healing rates at two, four, and six weeks were 40, 75, and 84 percent, respectively, for enprostil and 42, 77, and 87 percent, respectively, for cimetidine. There were no significant differences between treatments. Healing rates in both groups were reduced in smokers, in those with larger ulcers at baseline, and in those who reported a higher consumption of alcohol. Age, however, had no effect on healing rates. Digestive system complaints were reported more frequently in the enprostil group, whereas central nervous system complaints were more than twice as frequent in the cimetidine group. |
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Authors:
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L Winters |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of medicine Volume: 81 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1986 Aug |
Date Detail:
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Created Date: 1986-10-06 Completed Date: 1986-10-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 69-74 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Alcohol Drinking Belgium Cimetidine / administration & dosage, adverse effects, therapeutic use* Clinical Trials as Topic Double-Blind Method Duodenal Ulcer / drug therapy* Enprostil Female France Great Britain Humans Male Middle Aged Prostaglandins E, Synthetic / administration & dosage, adverse effects, therapeutic use* Random Allocation Smoking Sweden Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E, Synthetic; 51481-61-9/Cimetidine; 73121-56-9/Enprostil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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