Document Detail


Comparison of the efficacy and tolerability of lisinopril and sustained-release verapamil in black patients with hypertension.
MedLine Citation:
PMID:  1659495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this clinical study the efficacy and tolerability of lisinopril and sustained-release (SR) verapamil hydrochloride were compared in black patients with mild-to-moderate uncomplicated essential hypertension. The goal of therapy was to achieve a supine diastolic blood pressure (SDBP) of less than 90 mmHg or a greater than or equal to 10-mmHg fall in SDBP. Forty-three patients completed the titration phase, 23 in the lisinopril group and 20 in the verapamil SR group. The mean baseline supine systolic/diastolic blood pressures were 147/98 mmHg for the lisinopril group and 155/100 mmHg for the verapamil SR group. At the end of a two- to eight-week titration period, 87% of the lisinopril-treated patients and 90% of the verapamil SR-treated patients had achieved SDBP control. Six patients were excluded from maintenance therapy: four in the lisinopril group (one because of urticaria and three because of failure to reach goal blood pressure) and two in the verapamil SR group (because of failure to reach goal blood pressure). After eight weeks of maintenance therapy, 68% of the lisinopril-treated patients and 72% of the verapamil SR-treated patients had achieved SDBP control. The mean decreases in SDBP were comparable for both treatment groups. At the end of titration, the mean decreases from baseline were 10.5 mmHg for the lisinopril group and 12.6 mmHg for the verapamil SR group. At the end of maintenance, the mean decreases from baseline were 7.8 mmHg for the lisinopril group and 9.2 mmHg for the verapamil SR group. Adverse experiences were few.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
M R Weir; B W Kong; P Jenkins; P T Lavin
Related Documents :
10716135 - Efficacy and safety of valsartan compared with enalapril at different altitudes.
15096905 - Amlodipine 2.5 mg once daily in older hypertensives: a brazilian multi-centre study.
2908305 - Dose-effect relationship of carvedilol in essential hypertension. an open study.
3880995 - Comparison of acebutolol and propranolol in essential hypertension.
3942335 - Effects of clonidine on narcotic requirements and hemodynamic response during induction...
16365065 - Fish oil affects blood pressure and the plasma lipid profile in healthy danish infants.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical therapeutics     Volume:  13     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-16     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Maryland Hospital, Baltimore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group*
Aged
Blood Pressure / drug effects
Delayed-Action Preparations
Enalapril / administration & dosage,  analogs & derivatives*,  therapeutic use
Female
Humans
Hypertension / drug therapy*
Lisinopril
Male
Prospective Studies
United States
Verapamil / administration & dosage,  therapeutic use*
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 52-53-9/Verapamil; 75847-73-3/Enalapril; 83915-83-7/Lisinopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of the efficacy and tolerability of lisinopril and sustained-release verapamil in older p...
Next Document:  Regulation of plasma membrane permeability to calcium in primary cultures of rat hepatocytes.