Document Detail


Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias.
MedLine Citation:
PMID:  16636494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Suppression of implantable defibrillator discharges associated with ventricular tachyarrhythmia (VTA) has been reported for sotalol. This study aimed to investigate the efficacy of intravenous nifekalant hydrochloride in predicting the effects of oral sotalol. METHODS AND RESULTS: The present study included 14 patients who had sustained VTA associated with structural heart disease. All patients also had inducible VTA. To compare the effects of nifekalant and sotalol, programmed electrical stimulation was performed, in the basal state, after nifekalant administration, and after sotalol administration. Nifekalant and sotalol similarly prolonged the corrected QT interval and ventricular effective refractory periods, but the heart rate was slowed by sotalol only. In 4 of 5 patients whose VTA became non-inducible by nifekalant, subsequent treatment with sotalol also suppressed the inducible VTA. In all of the 9 patients non-responding to nifekalant, VTA remained inducible during sotalol treatment. Nifekalant accurately predicted the response to sotalol during electrophysiologic study in 13 of 14 patients. Of 11 patients who remained on sotalol, VTA recurred in 3 non-responders during a follow-up of 46 +/- 11 months. CONCLUSIONS: Nifekalant and sotalol had similar effects on inducible VTA. The response of inducible VTA to nifekalant may predict the clinical efficacy of sotalol.
Authors:
Hiroshi Watanabe; Masaomi Chinushi; Takashi Washizuka; Hirotaka Sugiura; Takashi Hirono; Yoshiyasu Aizawa; Satoru Komura; Yukio Hosaka; Yasutaka Tanabe; Hiroshi Furushima; Yoshifusa Aizawa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  70     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-25     Completed Date:  2006-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  583-7     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-0575, USA. hiroshi7@med.niigata-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Arrhythmia Agents / administration & dosage*
Drug Therapy, Combination
Electric Stimulation
Electrocardiography
Electrophysiology
Female
Heart Diseases / drug therapy,  physiopathology
Humans
Male
Middle Aged
Pyrimidinones / administration & dosage*
Recurrence / prevention & control
Sotalol / administration & dosage*
Tachycardia, Ventricular / drug therapy*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Pyrimidinones; 130656-51-8/MS 551; 3930-20-9/Sotalol

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