Document Detail

Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy.
MedLine Citation:
PMID:  19602758     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Office hysteroscopy with endometrial biopsy is usually the first investigation for abnormal uterine bleeding and other uterine diseases. AIMS: To evaluate the effect of oral drotaverine with mefenamic acid on pain perception during hysteroscopy and endometrial biopsy and to compare it with that of paracervical block using 1% lignocaine and with that of intravenous sedation using diazepam with pentazocine. SETTINGS AND DESIGN: Outpatient gynecological department and open randomized trial. MATERIALS AND METHODS: One hundred twenty women undergoing hysteroscopy and endometrial biopsy were randomized into 3 groups. Group I received tablet containing drotaverine hydrochloride (80 mg)+mefenamic acid (250 mg), group II received lignocaine paracervically and group III received intravenous diazepam. The intensity of pain during the procedure, 30 and 60 minutes later on visual analog scale (VAS) was assessed. STATISTICAL ANALYSIS: Statistical analysis was performed using Kruskal-Wallis test, with the Bonferroni correction, the t test, and the chi2 test. RESULTS: Groups were similar in age, parity, vaginal birth or relevant medical history. A statistically significant difference in pain scores was noted among the 3 groups during the procedure (group I, 4.13+/-1.28; group II, 5.93+/-1.26; group III, 5.58+/-1.51), (P<0.001); as well as 30 minutes later (group I, 1.78+/-0.89; group II, 2.53+/-0.81; group III, 2.23+/-0.94), (P<0.001) and 60 minutes later (group I, 1.2+/-0.46; group II, 1.98+/-0.83; group III, 1.68+/-0.75), (P<0.001). VAS at different time intervals among the groups was also statistically significant. No adverse effects were observed. CONCLUSIONS: Oral drotaverine with mefenamic acid is effective in women undergoing hysteroscopy and endometrial biopsy.
J B Sharma; J Aruna; Praveen Kumar; Kallol Kumar Roy; Neena Malhotra; Sunesh Kumar
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  63     ISSN:  0019-5359     ISO Abbreviation:  Indian J Med Sci     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  244-52     Citation Subset:  IM    
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
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MeSH Terms
Adjuvants, Anesthesia / administration & dosage
Analgesics / administration & dosage*
Anesthesia, Intravenous / methods*
Anesthesia, Obstetrical / methods*
Anesthetics, Intravenous / administration & dosage
Diazepam / administration & dosage
Drug Therapy, Combination
Endometrium / pathology
Hypnotics and Sedatives / administration & dosage
Hysteroscopy / methods*
Mefenamic Acid / administration & dosage
Middle Aged
Pain Measurement
Papaverine / administration & dosage,  analogs & derivatives*
Pentazocine / administration & dosage
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Analgesics; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 14009-24-6/drotaverin; 359-83-1/Pentazocine; 439-14-5/Diazepam; 58-74-2/Papaverine; 61-68-7/Mefenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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