| Comparison of the efficacy of nifekalant and amiodarone in a porcine model of cardiac arrest. | |
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MedLine Citation:
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PMID: 20627529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy of nifekalant and amiodarone in the treatment of cardiac arrest in a porcine model. METHODS: After 4min of untreated ventricular fibrillation, animals were randomly treated with nifekalant (2mgkg(-1)), amiodarone (5mgkg(-1)) or saline placebo (n=12 pigs per group). Precordial compression and ventilation were initiated after drug administration and defibrillation was attempted 2min later. Hemodynamics were continuously measured for 6h after successful resuscitation. RESULTS: Compared with saline, nifekalant and amiodarone equally decreased the number of electric shocks, defibrillation energy, epinephrine dose, and duration of cardiopulmonary resuscitation required for successful resuscitation (P<0.01). The incidence of restoration of spontaneous circulation (ROSC) and the 24-h survival rate were higher in both antiarrhythmic drug groups (P<0.05) vs. the saline group. Furthermore, post-resuscitation myocardial dysfunction at 4-6h after successful resuscitation was improved in animals given antiarrhythmic drugs as compared with the saline group (P<0.05). There were no differences between nifekalant and amiodarone for any of these parameters. CONCLUSION: The effect of nifekalant was similar to that of amiodarone for improving defibrillation efficacy and for the treatment of cardiac arrest. Administration of either nifekalant or amiodarone before defibrillation increased the ROSC and 24-h survival rates and improved post-resuscitation cardiac function in this porcine model. |
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Authors:
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Xian-Fei Ji; Chun-Sheng Li; Shuo Wang; Lin Yang; Lu-Hong Cong |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-06-02 |
Journal Detail:
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Title: Resuscitation Volume: 81 ISSN: 1873-1570 ISO Abbreviation: Resuscitation Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 1031-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, 8# Baijiazhuang Road, Chaoyang District, Beijing 100020, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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administration & dosage* Animals Anti-Arrhythmia Agents / administration & dosage* Cardiopulmonary Resuscitation / methods* Disease Models, Animal Dose-Response Relationship, Drug Heart Arrest / etiology, physiopathology, prevention & control* Heart Rate / drug effects, physiology Male Pyrimidinones / administration & dosage* Swine Treatment Outcome Ventricular Fibrillation / complications, drug therapy*, physiopathology Ventricular Function / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Pyrimidinones; 130656-51-8/MS 551; 1951-25-3/Amiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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