Document Detail


Comparison of the efficacy of nasal drop and nasal spray applications of fluticasone propionate in nasal polyps.
MedLine Citation:
PMID:  18443395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We assessed the efficacy of different forms of fluticasone propionate in the treatment of bilateral nasal polyposis in adult patients. PATIENTS AND METHODS: This double-blind, randomized, parallel group study included 34 patients, aged 16 years or over, with a diagnosis of bilateral nasal polyposis. The patients were randomized to three groups to receive fluticasone propionate in the form of aqueous nasal spray 100 microg twice daily, or nasal drop preparation 400 microg once or twice daily for 12 weeks. Once every four weeks, nasal volumes were measured by acoustic rhinometry and polyp size was assessed by a 4-mm rigid endoscope. Clinical symptom scores were assessed once a week. RESULTS: The mean nasal polyp scores decreased significantly in all the groups (p<0.005). Total nasal volume did not improve significantly with the nasal spray. Although single daily nasal drop application increased total nasal volume significantly only at the end of treatment (p<0.05), increases with twice daily application were significant at 4, 8, and 12 weeks, compared to the baseline values and corresponding values of the other two groups (p<0.005). Nasal blockage and rhinitis symptom scores improved in all the groups (p<0.05), but the difference from the baseline was highest with twice daily nasal drop application. Smelling showed a significant improvement only with twice daily nasal drop application (p<0.05). In none of the groups did nasal discomfort scores differ significantly from the baseline at the end of treatment. CONCLUSION: Nasal drop preparation of fluticasone propionate given twice daily showed the highest efficacy in increasing total nasal volume, decreasing nasal polyp size, and improving smelling and nasal blockage.
Authors:
Tayfun Demirel; Kadir Serkan Orhan; Nesil Keleş; Kemal Değer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat     Volume:  18     ISSN:  1300-7475     ISO Abbreviation:  Kulak Burun Bogaz Ihtis Derg     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-29     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100899230     Medline TA:  Kulak Burun Bogaz Ihtis Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Capa Hospital, Istanbul, Turkey. demireltayfun@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Intranasal
Adult
Aerosols
Aged
Androstadienes / administration & dosage*
Anti-Inflammatory Agents / administration & dosage*
Double-Blind Method
Endoscopy
Female
Humans
Male
Middle Aged
Nasal Obstruction / drug therapy,  etiology
Nasal Polyps / complications,  drug therapy*
Nose / drug effects,  pathology
Prospective Studies
Rhinitis / drug therapy,  etiology
Rhinometry, Acoustic
Smell / drug effects
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Aerosols; 0/Androstadienes; 0/Anti-Inflammatory Agents; 90566-53-3/fluticasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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