Document Detail

Comparison of the efficacy of diclofenac and betamethasone following strabismus surgery.
MedLine Citation:
PMID:  9215059     Owner:  NLM     Status:  MEDLINE    
AIMS: To compare the relative antiinflammatory potency and safety of topical diclofenac-gentamicin with betamethasone-neomycin following strabismus surgery. METHODS: A single centre, single observer, prospective, randomised, and double masked clinical trial of 25 children undergoing bilateral symmetrical horizontal strabismus surgery was carried out. One eye received diclofenac-gentamicin and the contralateral eye received betamethasone-neomycin; both treatments were instilled four times a day for 4 weeks postoperatively. Ocular inflammation was assessed at 1 and 4 weeks postoperatively, objectively by comparison with a photographic chart and subjectively by questionnaire. RESULTS: There was no statistically significant difference in the rate of resolution of the inflammatory response between each group at both visits. CONCLUSION: Diclofenac appears to be as effective as betamethasone in controlling postoperative inflammation following strabismus surgery and may offer a safer alternative to the use of topical steroids.
M Wright; Z Butt; G McIlwaine; B Fleck
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  81     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-21     Completed Date:  1997-07-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-301     Citation Subset:  IM    
Princess Alexandra Eye Pavilion, Edinburgh.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Betamethasone / therapeutic use*
Child, Preschool
Diclofenac / therapeutic use*
Double-Blind Method
Gentamicins / therapeutic use
Inflammation / prevention & control*
Neomycin / therapeutic use
Pain Measurement
Postoperative Complications / prevention & control*
Prospective Studies
Strabismus / surgery*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Gentamicins; 1404-04-2/Neomycin; 15307-86-5/Diclofenac; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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