| Comparison of the effects of vasopressin and norepinephrine on organ perfusion during septic shock in streptozotocin-induced diabetic rats. | |
| | |
MedLine Citation:
|
PMID: 20390307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The purpose of this study was to compare the effects of norepinephrine (NE) and vasopressin on systemic hemodynamics, renal and mesenteric artery blood flow, inflammatory response and inducible nitric oxide synthase (iNOS) activity during endotoxin shock in streptozotocin-induced diabetic rats. METHODS: The study was designed to include three sets of experiments: (1) measurement of changes in systemic hemodynamics and mesenteric and renal artery blood flow; (2) measurement of biochemical variables; and (3) measurement of iNOS activity in the mesenteric artery. Systemic hemodynamics, regional artery blood flow changes and biochemical variables were assessed before treatment and 1, 2 and 3 h after treatment. RESULTS: Vasopressin, but not NE, prevented the decreases in aortic blood flow, but did not restore mesenteric artery blood flow. In addition, vasopressin partially restored renal artery blood flow in diabetic rats. Plasma nitrite levels and iNOS activity in the mesenteric artery were elevated after intravenous LPS in diabetic rats. Endotoxin-induced decreases in mesenteric arterial blood flow were partially restored by vasopressin with nonselective NOS inhibitor, N G-nitro-l-arginine methyl ester (l-NAME), in diabetic rats. Moreover, l-NAME prevented increases in plasma nitrite levels and iNOS activity in the mesenteric artery. In contrast, endotoxin-induced decreases in renal arterial blood flow were partially restored by vasopressin with l-NAME, but not by NE in diabetic rats. CONCLUSIONS: Nitric oxide may be one possible contributor to reduced sensitivity of the mesenteric and renal arteries to vasopressin during septic shock in streptozotocin-induced diabetic rats. |
| | |
Authors:
|
Hiroshi Hinohara; Yuji Kadoi; Aya Tokue; Shigeru Saito; Chikara Kawauchi; Akio Mizutani |
Related Documents
:
|
9573597 - Continuous renal replacement therapy in critically ill patients. 3585907 - Long-acting angiotensin ii inhibitors containing hexafluorovaline in position 8. 7110467 - Renal handling of salt and water in the early stage of obstructive jaundice in rabbits. 7246777 - Effect of calcium on prostaglandin e2 release in dogs. 19707177 - Effect of bladderbox alarms during venoarterial extracorporeal membrane oxygenation on ... 9713847 - Hemodynamic sequelae of ventricular tachyarrhythmias on cerebral blood flow. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of anesthesia Volume: 24 ISSN: 1438-8359 ISO Abbreviation: J Anesth Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-16 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
|
Languages: eng Pagination: 553-63 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology, Graduate School of Medicine, Gunma University, 3-39-22 Showa-Machi, Maebashi, Gunma 371-8511, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Diabetes Mellitus, Experimental / physiopathology* Hemodynamics / drug effects* Male NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology Norepinephrine / pharmacology* Rats Rats, Wistar Renal Circulation / drug effects Shock, Septic / drug therapy*, physiopathology Splanchnic Circulation / drug effects Streptozocin Vasopressins / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 11000-17-2/Vasopressins; 18883-66-4/Streptozocin; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anesthesia protocols for early vitrectomy in former preterm infants diagnosed with aggressive poster...
Next Document: Toe gangrene in an infant subsequent to application of adult-type pulse oximeter probe for 10 min.