Document Detail

Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis.
MedLine Citation:
PMID:  9920517     Owner:  NLM     Status:  MEDLINE    
Fish oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been demonstrated to alter coagulation and fibrinolysis variables. This study compared the effects of a traditional cholesterol-lowering diet and a similar diet, which had 50% of the linoleic acid (LA) replaced with the 18 carbon n-3 fatty acid, alpha-linolenic acid (ALA), on selected hemostatic variables. After a 2-week run-in diet with 39.5% total energy (en) from fat, 29 healthy male subjects consumed a 31.5% en fat diet with approximately 7% en from polyunsaturated fat and an ALA:LA ratio of either 1:1.2 (ALA-rich, n=15) or 1:21 (LA-rich, n=14) for 6 weeks. Blood was collected at the beginning, middle and end of test diets for analysis of Factor VIIc and VIIIc, fibrinogen, von Willebrand factor, activated protein C resistance (APC resistance), tissue plasminogen activator and plasminogen activator inhibitor type-1 activities and/or protein concentrations and platelet fatty acids. The ALA-rich diet tripled the percentage of platelet EPA, (P < 0.0005) but had little effect on coagulation and fibrinolysis. The APC ratio demonstrated increased anticoagulant activity on the ALA-rich diet (P < 0.001) only. Studies in patients with vascular pathologies are indicated to corroborate the current findings. Greater ratios of ALA:LA, achievable only with greater amounts of polyunsaturated fat, may be necessary to produce the effects demonstrated after feeding fish oils.
M A Allman-Farinelli; D Hall; K Kingham; D Pang; P Petocz; E J Favaloro
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  142     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-03-24     Completed Date:  1999-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
The Department of Biochemistry, The University of Sydney, NSW, Australia.
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MeSH Terms
Blood Coagulation*
Blood Platelets / chemistry
Cholesterol, Dietary / administration & dosage
Diet, Fat-Restricted*
Factor VII / analysis
Factor VIII / analysis
Fatty Acids / analysis
Fibrinogen / analysis
Linoleic Acid / administration & dosage*
Plasminogen Activator Inhibitor 1 / blood
Protein C / analysis
Tissue Plasminogen Activator / blood
alpha-Linolenic Acid / administration & dosage*
von Willebrand Factor / analysis
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Fatty Acids; 0/Plasminogen Activator Inhibitor 1; 0/Protein C; 0/von Willebrand Factor; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 9001-25-6/Factor VII; 9001-27-8/Factor VIII; 9001-32-5/Fibrinogen; EC Plasminogen Activator

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