Document Detail


Comparison of effects of topical ibopamine and epinephrine on the circadian rhythm of intraocular pressure of the rabbit eye as measured by telemetry.
MedLine Citation:
PMID:  10229488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to measure the effect of topical ibopamine and epinephrine on intraocular pressure in undisturbed rabbits. Six pigmented rabbits were outfitted with a telemetric transducer system connected via catheter to the vitreous cavity of one eye for continuous monitoring of intraocular pressure. After entrainment to a 12 hour light, 12 hour dark cycle and after stabilization of the circadian rhythm of intraocular pressure, the animals were tested with 2% ibopamine and 2% epinephrine. Each drug was instilled during the light phase and during the dark phase of the circadian cycle. When administered during the light phase, both drugs caused a transient pressure rise followed by prolonged hypotension. When administered during the dark phase, neither drug caused a pressure rise but both drugs caused prolonged hypotension. It was concluded that ibopamine and epinephrine cause identical intraocular pressure changes in the normal rabbit eye. The effect was dependent on the timing of administration during the circadian cycle. Since ibopamine is a pro-drug of deoxyepinephrine (N-methyl dopamine, epinine), its effects are assumed to be due to this metabolite, a metabolite that is structurally similar to epinephrine.
Authors:
J W McLaren; L A Bachman; R F Brubaker
Related Documents :
3741248 - Intraocular pressure elevation after pupillary dilation in open angle glaucoma.
15834078 - Clinical evaluation of the pressure phosphene tonometer in patients with glaucoma.
2383198 - The effect of adding prostaglandin f2 alpha-isopropylester to timolol in patients with ...
6546978 - The reopening of closed filtering blebs using the neodymium: yag laser.
23058098 - A closed-loop system for control of the fraction of inspired oxygen and the positive en...
6852438 - Experimental production of portal hypertension in dogs by a whole liver compression.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics     Volume:  15     ISSN:  1080-7683     ISO Abbreviation:  J Ocul Pharmacol Ther     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9511091     Medline TA:  J Ocul Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm / drug effects*
Deoxyepinephrine / analogs & derivatives*,  pharmacology
Epinephrine / pharmacology*
Intraocular Pressure / drug effects*
Mydriatics / pharmacology*
Rabbits
Telemetry
Grant Support
ID/Acronym/Agency:
EY 00634/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Mydriatics; 501-15-5/Deoxyepinephrine; 51-43-4/Epinephrine; 66195-31-1/ibopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relationship between acetazolamide blood concentration and its side effects in glaucomatous patients...
Next Document:  Safety and ocular hypotensive efficacy of a single dose of metoclopramide or droperidol in healthy s...