| Comparison of the effects of streptokinase and heparin on the early rate of resolution of major pulmonary embolism. | |
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MedLine Citation:
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PMID: 5549989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extent of early resolution of major pulmonary embolism observed in 10 patients after 24 hours of treatment with heparin was compared with that seen in 17 patients after 24 hours of treatment with streptokinase. The patients in the streptokinase group also received a loading dose of heparin and were treated with heparin by continuous infusion when their thrombin time returned to normal levels. All had pulmonary hypertension. Pulmonary embolism was classified as acute in the 10 patients in the heparin group. Seven of these patients showed no angiographic change, two showed slight improvement and one showed angiographic deterioration. There was a moderate and statistically insignificant fall in mean pulmonary arterial pressure and total pulmonary resistance. Fourteen of the 17 patients who were studied before and after streptokinase were classified as acute and three as subacute progressive major pulmonary embolism. Eight showed marked angiographic improvement, four moderate and two slight angiographic improvement. There was a moderate and statistically significant fall in the mean pulmonary arterial pressure and pulmonary vascular resistance. In addition, all seven patients in whom no angiographic improvement occurred during heparin therapy showed moderate or marked angiographic improvement after a further 24 hours of treatment with streptokinase. The results strongly suggest that streptokinase therapy accelerates thrombolysis in patients with acute major pulmonary embolism. |
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Authors:
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J Hirsh; I G McDonald; G A Hale; E F O'Sullivan; V M Jelinek |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Canadian Medical Association journal Volume: 104 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1971 Mar |
Date Detail:
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Created Date: 1971-05-17 Completed Date: 1971-05-17 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 488-91 passim Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Blood Coagulation Tests Female Hemodynamics Heparin / therapeutic use* Humans Male Middle Aged Pulmonary Circulation / drug effects Pulmonary Embolism / drug therapy*, radiography Streptokinase / therapeutic use* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin; EC 3.4.-/Streptokinase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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