Document Detail


Comparison of the effects of sevoflurane and isoflurane on arterial oxygenation during one lung ventilation.
MedLine Citation:
PMID:  10211007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have compared the effects of sevoflurane and isoflurane on arterial oxygenation, heart rate and mean arterial pressure during one lung anaesthesia in a prospective, crossover study. We studied 28 patients undergoing oesophagogastrectomy, allocated alternatively to one of two groups. Patients in group I/S (n = 14) received 1 MAC (1.1%) of isoflurane in oxygen from induction until the end of 30 min of open chest one lung ventilation (OLV) in the lateral position. This was followed by 1 MAC (2.1%) of sevoflurane in oxygen for the next 30 min of OLV. Patients in group S/I (n = 14) received the two anaesthetic agents in the reverse order. We found no significant difference in arterial oxygenation, heart rate or mean arterial pressure between the two potent inhalation agents. In the subgroup of patients with pulmonary artery catheters (n = 12), we found a significant increase (P < 0.05) in derived shunt during sevoflurane anaesthesia. There was no significant difference in mixed venous saturation and cardiac output. We conclude that during one lung ventilation, the choice between sevoflurane and isoflurane did not significantly influence arterial oxygenation.
Authors:
J Y Wang; G N Russell; R D Page; M Jackson; S H Pennefather
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  81     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-27     Completed Date:  1999-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  850-3     Citation Subset:  IM    
Affiliation:
Cardiothoracic Centre, Liverpool.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anesthetics, Inhalation / pharmacology*
Arteries
Cross-Over Studies
Esophagectomy
Female
Gastrectomy
Hemodynamics / drug effects
Humans
Isoflurane / pharmacology*
Male
Methyl Ethers / pharmacology*
Middle Aged
Oxygen / blood*
Partial Pressure
Prospective Studies
Respiration, Artificial / methods*
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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