| Comparison of the effects of sevoflurane and isoflurane on arterial oxygenation during one lung ventilation. | |
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MedLine Citation:
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PMID: 10211007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have compared the effects of sevoflurane and isoflurane on arterial oxygenation, heart rate and mean arterial pressure during one lung anaesthesia in a prospective, crossover study. We studied 28 patients undergoing oesophagogastrectomy, allocated alternatively to one of two groups. Patients in group I/S (n = 14) received 1 MAC (1.1%) of isoflurane in oxygen from induction until the end of 30 min of open chest one lung ventilation (OLV) in the lateral position. This was followed by 1 MAC (2.1%) of sevoflurane in oxygen for the next 30 min of OLV. Patients in group S/I (n = 14) received the two anaesthetic agents in the reverse order. We found no significant difference in arterial oxygenation, heart rate or mean arterial pressure between the two potent inhalation agents. In the subgroup of patients with pulmonary artery catheters (n = 12), we found a significant increase (P < 0.05) in derived shunt during sevoflurane anaesthesia. There was no significant difference in mixed venous saturation and cardiac output. We conclude that during one lung ventilation, the choice between sevoflurane and isoflurane did not significantly influence arterial oxygenation. |
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Authors:
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J Y Wang; G N Russell; R D Page; M Jackson; S H Pennefather |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 81 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-04-27 Completed Date: 1999-04-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 850-3 Citation Subset: IM |
Affiliation:
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Cardiothoracic Centre, Liverpool. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anesthetics, Inhalation / pharmacology* Arteries Cross-Over Studies Esophagectomy Female Gastrectomy Hemodynamics / drug effects Humans Isoflurane / pharmacology* Male Methyl Ethers / pharmacology* Middle Aged Oxygen / blood* Partial Pressure Prospective Studies Respiration, Artificial / methods* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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