Document Detail

Comparison of the effects of propofol and halothane on acute myocardial ischaemia and myocardial reperfusion injury.
MedLine Citation:
PMID:  8711582     Owner:  NLM     Status:  MEDLINE    
The effects of two blood concentrations of propofol on acute severe regional myocardial ischaemia (15-minute occlusion of the LAD coronary artery) and 2-hour reperfusion were studied in 10 pigs. Results were contrasted with the effect of 0.8% halothane (N = 5). Results indicate that during acute ischaemia, regional myocardial function of the segment supplied by the LAD artery was not protected against the effects of ischaemia in the propofol or halothane groups. During reperfusion, animals subjected to halothane demonstrated significantly fewer reperfusion arrhythmias and segmental function was less stunned than in either propofol group. There was no difference in heart performance between the propofol groups. Results indicate that the proposed anti-oxidant effect of propofol is not sufficient to protect the animal heart from reperfusion injury.
A Coetzee
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  86 Suppl 2     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-10     Completed Date:  1996-09-10     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  C85-90     Citation Subset:  IM    
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MeSH Terms
Anesthetics, Inhalation / administration & dosage,  therapeutic use*
Free Radical Scavengers / administration & dosage,  therapeutic use*
Halothane / administration & dosage,  therapeutic use*
Myocardial Ischemia / drug therapy*
Propofol / administration & dosage,  therapeutic use*
Reperfusion Injury / drug therapy*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Free Radical Scavengers; UQT9G45D1P/Halothane; YI7VU623SF/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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