| Comparison of effects on peak oxygen consumption, quality of life, and neurohormones of felodipine and enalapril in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 7503006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin-converting enzyme (ACE) inhibition is currently the cornerstone of congestive heart failure (CHF) therapy, but these drugs are not tolerated in up to 20% of patients. For these patients, therapeutic alternatives with comparable efficacy are needed. Felodipine, a vasoselective dihydropyridine calcium antagonist with a slow onset of action and a long plasma half-life, may be such an agent. Therefore, the efficacy and safety of felodipine were examined and compared with enalapril using a double-blind design. We studied 46 patients with a left ventricular ejection fraction < 0.40, peak oxygen consumption < 20 ml.min-1.kg-1, and symptoms of CHF despite therapy with diuretics and digoxin. After 16 weeks of therapy, there were no statistically significant differences in peak oxygen consumption (felodipine +1.6, enalapril +2.5 ml.min-1.kg-1) and exercise tolerance (felodipine +61 seconds, enalapril +64 seconds). Quality-of-life parameters were affected slightly better by felodipine than by enalapril. Plasma norepinephrine decreased by 143 pg.ml-1 with enalapril and by 12 pg.ml-1 with felodipine (p < 0.20 between groups). Both drugs were generally well tolerated. These data suggest that felodipine and enalapril have comparable effects on exercise parameters in patients with CHF. Neurohumoral activation was not observed with either drug. |
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Authors:
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R J de Vries; M Queré; D J Lok; P Sijbring; J J Bucx; D J van Veldhuisen; P H Dunselman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 76 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-01-18 Completed Date: 1996-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1253-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Ignatius Hospital, Breda, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aldosterone / blood Angiotensin-Converting Enzyme Inhibitors / adverse effects, therapeutic use* Calcium Channel Blockers / adverse effects, pharmacology, therapeutic use* Double-Blind Method Enalapril / adverse effects, therapeutic use* Exercise Tolerance / drug effects Felodipine / adverse effects, pharmacology, therapeutic use* Female Heart Failure / blood, drug therapy*, physiopathology Humans Male Middle Aged Norepinephrine / blood Oxygen Consumption / drug effects Quality of Life Renin / blood Vasodilator Agents / adverse effects, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 52-39-1/Aldosterone; 72509-76-3/Felodipine; 75847-73-3/Enalapril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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