| Comparison of the effects of oral versus intravenous methylprednisolone regimens on peripheral blood T lymphocyte adhesion molecule expression, T cell subsets distribution and TNF alpha concentrations in multiple sclerosis. | |
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MedLine Citation:
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PMID: 9119980 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated in multiple sclerosis the difference between two commonly used oral and intravenous steroid regimens on the level of adhesion molecule expression on blood T lymphocytes, the distribution of circulating T cell subsets, and the concentration of serum tumour necrosis factor alpha. Venous blood samples were collected from a cohort of 22 patients with acute relapses who were participating in a randomised trial comparing intravenous methylprednisolone 1000 mg daily for 3 days with oral methylprednisolone 48 mg daily for one week, 24 mg daily for one week, and finally 12 mg daily for one week. There was a similar significant reduction of T cell LFA-1 surface expression and serum TNF alpha concentrations after 4 days of treatment with each regimen. There was no change in other lymphocyte adhesion molecules expression (ICAM-1, LFA-3 or CD2) at day 4, although LFA-3 and CD2 expression was moderately decreased at day 28 and day 90 respectively; nor was there any change in the distribution of lymphocyte subsets (CD4, CD8, and CD45RA, CD45RO), although a small decrease in CD45RO circulatory T cells was noted at day 28. This study suggests that some of the beneficial effects of glucocorticosteroids may be related to the inhibition of lymphocyte adhesion as well as the modulation of proinflammatory cytokines. |
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Authors:
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C Pitzalis; B Sharrack; I A Gray; A Lee; R A Hughes |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 74 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 62-8 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, UMDS, Guy's Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Cell Adhesion Molecules / blood* Cell Membrane / drug effects, metabolism Double-Blind Method Glucocorticoids / administration & dosage*, therapeutic use Humans Injections, Intravenous Methylprednisolone / administration & dosage*, therapeutic use Multiple Sclerosis / blood, drug therapy* Osmolar Concentration T-Lymphocyte Subsets / drug effects T-Lymphocytes / metabolism* Tissue Distribution Tumor Necrosis Factor-alpha / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Glucocorticoids; 0/Tumor Necrosis Factor-alpha; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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