Document Detail

Comparison of effects of nitrendipine, lacidipine and mibefradil on postischaemic myocardial damage in isolated rat hearts.
MedLine Citation:
PMID:  11005649     Owner:  NLM     Status:  MEDLINE    
During ischaemia and reperfusion increased cytosolic Ca2+ is one of the important causes for ischaemic-reperfusion myocardial injury. In the present study we compared effects of preferentially L-type Ca2+ antagonists nitrendipine (NT) and lacidipine (LP), and of mibefradil (MB) a Ca2+ antagonist with higher affinity to T- than to L-type channels on myocardial function during reperfusion. Coronary flow (CF), heart rate (HR), left ventricular pressure (LVP), lactate dehydrogenase (LDH) release rate and ECG were registered during 40 min of reperfusion following 30 min of global zero flow ischaemia in Langendorff's isolated rat hearts. Either NT (100 nmol/L) or LP (10 nmol/L) or MB (100 nmol/L) was added to Krebs-Henseleit solution 10 min before ischaemia till the end of experiments. All three drugs influenced CF, HR and LVP. All of them decreased LDH release rate (P < 0.05, in microkat/g x min) when compared with control hearts (53.2 +/- 5.1): MB (19.4 +/- 4.3) > LP (30.7 +/- 6.6) > NT (43.3 +/- 2.8). NT reduced the duration of continuous arrhythmias at the beginning of reperfusion (to 59.1 +/- 6.1% of ischaemic controls) as well as the number of single arrhythmic events arising during the whole period of reperfusion (to 26.1 +/- 6.0% of ischaemic controls). MB diminished only single arrhythmic events during reperfusion to 39.1 +/- 17.3% of ischaemic controls. LP did not affect the onset of arrhythmias. Results of our experiments indicate a relatively greater importance of T-type than of L-type Ca2+ channels in the arising of postischaemic myocardial damage.
M Arh; M V Budihna
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  440     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  R149-50     Citation Subset:  IM    
Department of Pharmacology and Experimental Toxicology, Faculty of Medicine, Ljubljana, Slovenia.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Calcium Channel Blockers / pharmacology*
Coronary Circulation / drug effects
Dihydropyridines / pharmacology*
Heart / drug effects,  physiopathology
Hemodynamics / drug effects
Mibefradil / pharmacology*
Myocardial Ischemia / physiopathology*
Myocardial Reperfusion Injury / physiopathology*
Nitrendipine / pharmacology*
Rats, Wistar
Reference Values
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 103890-78-4/lacidipine; 116644-53-2/Mibefradil; 39562-70-4/Nitrendipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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