Document Detail


Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardiac function in conscious dogs.
MedLine Citation:
PMID:  6403258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of nifedipine, 20 micrograms/kg, iv, and nitroglycerin, 25 micrograms/kg, iv, were compared in conscious dogs, instrumented for instantaneous and continuous measurements of coronary arterial and left ventricular (LV) diameters, arterial and LV pressures, coronary blood flow, and cardiac output. The two drugs were administered to reduce arterial pressure initially by similar amounts, by approximately 30 mm Hg. The maximal increases in large coronary arterial dimensions occurred 2-4 minutes after the initial peak reductions in arterial pressure and increases in coronary blood flow. The maximal increase in large coronary arterial cross-sectional area with nifedipine (28 +/- 2.9%) and nitroglycerin (33 +/- 5.3%) were similar. At this time, nifedipine increased coronary blood flow (114 +/- 20%) and reduced late diastolic coronary vascular resistance (-61 +/- 3.1%), whereas nitroglycerin reduced coronary blood flow (-14 +/- 1.7%) and increased late diastolic coronary vascular resistance (15 +/- 6.6%). During the time of peak large coronary arterial dilation, nifedipine reduced mean arterial pressure (-13 +/- 2.1%) and total peripheral resistance (-30 +/- 2.6%), whereas, with nitroglycerin, arterial pressure was not different from control and total peripheral resistance was significantly increased (13 +/- 1.8%). At this time, LV end-diastolic diameter was reduced with nitroglycerin (-5.6 +/- 0.4%) but unaffected by nifedipine. Thus, in the conscious dog, nitroglycerin and nifedipine induced similar effects on large coronary arteries but differing effects on resistance coronary and peripheral vessels as well as preload. Nifedipine, in contrast to nitroglycerin, induced sustained vasodilation of both coronary resistance vessels and peripheral arterioles, whereas nitroglycerin, but not nifedipine, reduced preload.
Authors:
T H Hintze; S F Vatner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  52     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I139-46     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Circulation / drug effects
Coronary Disease / drug therapy
Coronary Vessels / drug effects*
Dogs
Heart / drug effects*
Nifedipine / pharmacology*
Nitroglycerin / pharmacology*
Pyridines / pharmacology*
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
HL 05936/HL/NHLBI NIH HHS; HL 15416/HL/NHLBI NIH HHS; HL 17459/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Pyridines; 21829-25-4/Nifedipine; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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