Document Detail


A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat.
MedLine Citation:
PMID:  23016598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The primary goal of this study was to compare clinically relevant doses of progesterone and nicotinamide within the same injury model. Progesterone has been shown to reduce edema and inflammation and improve functional outcomes following brain injury. Nicotinamide has also been shown to be an effective neuroprotective agent in a variety of neurological injury models. In the current study, nicotinamide was administered beginning 4 h post-cortical contusion injury (CCI) with a loading dose (75 mg/kg, i.p.) combined with continuous infusion (12 mg/h/kg, s.c.) for 72 h post-injury. Progesterone was administered beginning 4 h post-CCI at a dose of 10 or 20 mg/kg, i.p. every 12 h for 72 h. This resulted in the following groups: Injured-nicotinamide treated, Injured-progesterone-10 treated, Injured-progesterone-20 treated, Injured-vehicle treated, and Sham. Functional recovery was assessed with two spatial memory tasks in the Morris water maze (MWM) the acquisition of a reference memory task and a reversal learning task. Neuropathological assessments were conducted in the cortex and hippocampus. It was found that both progesterone (10 mg/kg) and nicotinamide improved reference memory acquisition and reversal learning in the MWM compared with vehicle treatment. The lower dose of progesterone and nicotinamide also reduced tissue loss in the injured cortex and ipsilateral hippocampus compared with vehicle. The beneficial effects of progesterone appear to be dose dependent with the lower 10 mg/kg dose producing significant effects that were not observed at the higher dose. Direct comparison between nicotinamide and low dose progesterone appears to suggest that both are equally effective. The general findings of this study suggest that both nicotinamide and progesterone produce significant improvements in recovery of function following CCI.
Authors:
Todd C Peterson; Gail D Anderson; Eric D Kantor; Michael R Hoane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-27
Journal Detail:
Title:  Journal of neurotrauma     Volume:  29     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-21     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2823-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / drug effects*
Brain / pathology
Brain Injuries / drug therapy*,  pathology,  psychology*
Cognition / drug effects*
Hippocampus / pathology
Infusion Pumps, Implantable
Learning / physiology
Male
Maze Learning / drug effects
Memory, Long-Term / drug effects
Neurosurgical Procedures
Niacinamide / administration & dosage,  therapeutic use*
Progesterone / administration & dosage,  therapeutic use*
Rats
Rats, Sprague-Dawley
Recovery of Function
Reversal Learning / physiology
Grant Support
ID/Acronym/Agency:
R01 HD061944/HD/NICHD NIH HHS; R01 HD061944-01/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
25X51I8RD4/Niacinamide; 4G7DS2Q64Y/Progesterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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