Document Detail


Comparison of the effects of mechanical and osmotic pressures on the collagen fiber architecture of intact and proteoglycan-depleted articular cartilage.
MedLine Citation:
PMID:  17021804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the functions of articular cartilage is to withstand recurrent pressure applied in everyday life. In previous studies, osmotic pressure has been used to mimic the effects of mechanical pressure. In the present study, the response of the collagen network of intact and proteoglycans (PG)-depleted cartilage to mechanical and osmotic pressures is compared. The technique used is one-dimensional (2)H double quantum filtered spectroscopic MRI, which gives information about the degree of order and the density of the collagen fibers at the different locations throughout the intact tissue. For the nonpressurized plugs, the depletion had no effect on these parameters. Major differences were found in the zones near the bone between the effects of the two types of application of pressure for both intact and depleted plugs. While the order is lost in these zones as a result of mechanical load, it is preserved under osmotic pressure. For both intact and PG-depleted plugs under osmotic stress most of the collagen fibers become disordered. Our results indicate that different modes of strain are produced by unidirectional mechanical load and the isotropic osmotic stress. Thus, osmotic stress cannot serve as a model for the effect of load on cartilage in vivo.
Authors:
Galit Saar; Hadassah Shinar; Gil Navon
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-22
Journal Detail:
Title:  European biophysics journal : EBJ     Volume:  36     ISSN:  0175-7571     ISO Abbreviation:  Eur. Biophys. J.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-18     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409413     Medline TA:  Eur Biophys J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  529-38     Citation Subset:  IM    
Affiliation:
School of Chemistry, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. navon@post.tau.ac.il
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MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage, Articular / physiology*
Cattle
Fibrillar Collagens / physiology*,  ultrastructure*
Mechanotransduction, Cellular / physiology*
Osmotic Pressure
Pressure
Proteoglycans / metabolism*
Chemical
Reg. No./Substance:
0/Fibrillar Collagens; 0/Proteoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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