| Comparison of the effects of low-flow and high-flow inhalational anaesthesia with nitrous oxide and desflurane on mucociliary activity and pulmonary function tests. | |
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MedLine Citation:
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PMID: 21119518 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the effects of inhalational anaesthesia using low and high gas flow rates of nitrous oxide and desflurane on mucociliary clearance and pulmonary function. METHODS: Fifty adult patients of the American Society of Anesthesiologists physical status I-II, aged between 18 and 70 years, were recruited to the study. Patients were assigned randomly to one of two study groups. The fresh gas flow rate was 1 l min (0.5 l min O2 + 0.5 l min N2O + desflurane) in group 1 and 3 l min (1.5 l min O2 + 1.5 l min N2O + desflurane) in group 2. Patients' haemodynamic parameters and changes in the humidity and temperature of the inspired gases were recorded and the saccharin clearance time was measured before and after anaesthesia. Respiratory parameters, body temperature, end-tidal CO2 concentration and inspired and expired oxygen and nitrous oxide concentrations were also recorded. RESULTS: The forced vital capacity and forced expiratory volume in 1 s were significantly lower and the saccharin clearance time was significantly longer in group 2 compared to group 1 (P < 0.05). There were statistically significant differences between the groups regarding the humidity and temperature of the inspired gases (P < 0.05). CONCLUSION: Respiratory function and mucociliary clearance are better preserved in a low-flow anaesthesia technique than in high-flow anaesthesia with nitrous oxide and desflurane. Therefore, a low-flow anaesthesia technique with nitrous oxide and desflurane may provide an important clinical advantage because it provides appropriately heated and humidified gases to the tracheobronchial tree. |
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Authors:
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Murat Bilgi; Sitki Goksu; Ayse Mizrak; Cengiz Cevik; Rauf Gul; Senem Koruk; Levent Sahin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 28 ISSN: 1365-2346 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 279-83 Citation Subset: IM |
Affiliation:
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From the Department of Anesthesiology and Reanimation (MB, SG, AM, RG, SK, LS) and the Department of Ear Nose Throat Surgery, Gaziantep University School of Medicine (CC), Gaziantep, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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