Document Detail

Comparison of the effects of the levonorgestrel-releasing intrauterine system (Mirena) and depot-medroxyprogesterone acetate (Depo-Provera) on subendometrial microvascularisation and uterine artery blood flow.
MedLine Citation:
PMID:  19565422     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the effects of the levonorgestrel-intrauterine system (LNG-IUS) and depot-medroxyprogesterone acetate (DMPA) on subendometrial vascularisation and uterine artery blood flow. STUDY DESIGN: The trial compared 25 patients wearing a LNG-IUS and 25 patients receiving DMPA. The subendometrial blood flow was evaluated using power Doppler analysis; the pulsatility index (PI) and resistance index (RI) in the uterine artery and spiral arteries were evaluated with spectral Doppler. RESULTS: The PI and RI of the uterine artery and endometrial thickness did not differ significantly between the two groups. The subendometrial vascularisation was lower and the PI in the spiral arteries was higher in DMPA-users. CONCLUSION: In spite of a similar prevalence of bleeding disturbances, the effects of DMPA and the LNG-IUS on the subendometrial microvascularisation differ.
Banu Dane; Aysu Akca; Cem Dane; Serap Evcimen; Ahmet Cetin
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception     Volume:  14     ISSN:  1473-0782     ISO Abbreviation:  Eur J Contracept Reprod Health Care     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-10-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9712127     Medline TA:  Eur J Contracept Reprod Health Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  IM    
Department of Gynaecology & Obstetrics, Haseki Training & Research Hospital, Istanbul, Turkey.
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MeSH Terms
Contraceptive Agents, Female / pharmacology*
Delayed-Action Preparations
Drug Administration Schedule
Endometrium / drug effects,  physiopathology
Intrauterine Devices, Medicated*
Levonorgestrel / pharmacology*
Medroxyprogesterone Acetate / pharmacology*
Middle Aged
Ultrasonography, Doppler
Uterus / blood supply*,  drug effects*,  physiopathology
Young Adult
Reg. No./Substance:
0/Contraceptive Agents, Female; 0/Delayed-Action Preparations; 71-58-9/Medroxyprogesterone Acetate; 797-63-7/Levonorgestrel

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