| Comparison of the effects of the levonorgestrel-releasing intrauterine system (Mirena) and depot-medroxyprogesterone acetate (Depo-Provera) on subendometrial microvascularisation and uterine artery blood flow. | |
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MedLine Citation:
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PMID: 19565422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effects of the levonorgestrel-intrauterine system (LNG-IUS) and depot-medroxyprogesterone acetate (DMPA) on subendometrial vascularisation and uterine artery blood flow. STUDY DESIGN: The trial compared 25 patients wearing a LNG-IUS and 25 patients receiving DMPA. The subendometrial blood flow was evaluated using power Doppler analysis; the pulsatility index (PI) and resistance index (RI) in the uterine artery and spiral arteries were evaluated with spectral Doppler. RESULTS: The PI and RI of the uterine artery and endometrial thickness did not differ significantly between the two groups. The subendometrial vascularisation was lower and the PI in the spiral arteries was higher in DMPA-users. CONCLUSION: In spite of a similar prevalence of bleeding disturbances, the effects of DMPA and the LNG-IUS on the subendometrial microvascularisation differ. |
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Authors:
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Banu Dane; Aysu Akca; Cem Dane; Serap Evcimen; Ahmet Cetin |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception Volume: 14 ISSN: 1473-0782 ISO Abbreviation: Eur J Contracept Reprod Health Care Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-30 Completed Date: 2009-10-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9712127 Medline TA: Eur J Contracept Reprod Health Care Country: England |
Other Details:
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Languages: eng Pagination: 240-4 Citation Subset: IM |
Affiliation:
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Department of Gynaecology & Obstetrics, Haseki Training & Research Hospital, Istanbul, Turkey. banudane@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contraceptive Agents, Female / pharmacology* Delayed-Action Preparations Drug Administration Schedule Endometrium / drug effects, physiopathology Female Humans Intrauterine Devices, Medicated* Levonorgestrel / pharmacology* Medroxyprogesterone Acetate / pharmacology* Middle Aged Ultrasonography, Doppler Uterus / blood supply*, drug effects*, physiopathology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Contraceptive Agents, Female; 0/Delayed-Action Preparations; 71-58-9/Medroxyprogesterone Acetate; 797-63-7/Levonorgestrel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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