Document Detail

Comparison of the effects of intrathecal morphine and pethidine on shivering after Caesarean delivery under combined-spinal epidural anaesthesia.
MedLine Citation:
PMID:  16288613     Owner:  NLM     Status:  MEDLINE    
We performed a prospective, randomised, double blind study to compare the antishivering effect of morphine and pethidine when added to intrathecal hyperbaric bupivacaine during elective Caesarean delivery under combined-spinal epidural anaesthesia. Spinal anaesthesia consisted of either 8-10 mg of 0.5% bupivacaine alone (group B; n = 30) with 0.1 mg morphine (group BM0.1; n = 29), with 0.2 mg morphine (group BM0.2; n = 30), or with 10 mg pethidine (group BPeth10; n = 30). The incidences of shivering were 23.3% (7/30) in group B, 17% (5/29) in group BM0.1, 13.3% (4/30) in group BM0.2 and 3.3% (1/30) in group BPeth10 (p < 0.05). The shivering intensity for each patient was significantly higher in group B than the other groups. In conclusion, intrathecal pethidine added to hyperbaric bupivacaine reduces the incidence and intensity of shivering more than does morphine (0.1 or 0.2 mg).
J-Y Hong; I H Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2005-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1168-72     Citation Subset:  AIM; IM    
Department of Anaesthesiology, Samsung Cheil Hospital, Sungkyunkwan University, Mukjeong-Dong 1-19, Jung-Gu, Seoul (100-380), South Korea.
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MeSH Terms
Analgesics, Opioid / pharmacology
Anesthesia, Epidural
Anesthesia, Obstetrical / methods*
Anesthesia, Spinal
Body Temperature / drug effects
Cesarean Section*
Double-Blind Method
Meperidine / pharmacology*
Morphine / pharmacology*
Postoperative Complications / prevention & control
Prospective Studies
Shivering / drug effects*
Reg. No./Substance:
0/Analgesics, Opioid; 57-27-2/Morphine; 57-42-1/Meperidine
Comment In:
Anaesthesia. 2006 Jun;61(6):612   [PMID:  16704613 ]

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