Document Detail

Comparison of the effects of intracerebrally administered MPP+ (1-methyl-4-phenylpyridinium) in three species: microdialysis of dopamine and metabolites in mouse, rat and monkey striatum.
MedLine Citation:
PMID:  2601882     Owner:  NLM     Status:  MEDLINE    
Intracerebral microdialysis in 3 awake species allowed the measurement of the basal output of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5-HIAA) from rat and mouse striatum and monkey caudate in vivo. The DOPAC/HVA ratios in dialysates from mouse and rat striatum were about 1 and 2 respectively, but only 0.09 in monkey caudate dialysates. The extracellular levels of the metabolites correlated well with reported tissue levels, while extracellular DA levels were 3 orders of magnitude lower than tissue concentrations. The effects of the intracerebrally administered dopaminergic neurotoxin 1-methyl-4-phenylpyridinium (MPP+) were essentially similar in the 3 species. In all cases an immediate, massive release of DA was accompanied by a pronounced decrease in the output of the metabolites. Basal DA release was no longer detectable 5-12 h after MPP+ administration and a second MPP+ perfusion failed to increase the release of DA.
H Rollema; G M Alexander; J R Grothusen; F F Matos; N Castagnoli
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  106     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-26     Completed Date:  1990-01-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
Division of Toxicology, School of Pharmacy, University of California, San Francisco 94143.
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MeSH Terms
1-Methyl-4-phenylpyridinium / pharmacology*
3,4-Dihydroxyphenylacetic Acid / metabolism
Corpus Striatum / drug effects,  metabolism*
Dopamine / metabolism*
Homovanillic Acid / metabolism
Macaca fascicularis
Mice, Inbred C57BL
Rats, Inbred Strains
Species Specificity
Grant Support
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 48134-75-4/1-Methyl-4-phenylpyridinium

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