| Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension. | |
| | |
MedLine Citation:
|
PMID: 19633451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The effects of indapamide, a thiazide-like diuretic, and captopril, an angiotensin-converting enzyme inhibitor, on spontaneous hypertension and the development of left ventricular hypertrophy (LVH), nitric oxide generation and oxidant status were investigated. METHODS: Six-week-old male spontaneously hypertensive rats (SHR) were treated with indapamide (1 mg/kg per day) or captopril (10 mg/kg per day) or a combination of indapamide plus captopril. After the 6-week treatment, nitric oxide synthase (NOS) activity, the expression of NOS isoform proteins, conjugated dienes concentration and relaxation responses of the femoral artery were analyzed. RESULTS: Indapamide and captopril partly prevented a blood pressure increase in young SHR. Captopril in contrast to indapamide reduced LVH. The effect of the combined indapamide and captopril treatment on the prevention of hypertension was additive. Combined indapamide and captopril treatment increased NOS activity and endothelial NOS protein expression in the aorta and decreased conjugated dienes concentration in the kidney compared with the indapamide monotherapy group. Indapamide and indapamide and captopril treatment increased acetylcholine-induced relaxation of the femoral artery. CONCLUSION: Whereas captopril reduced LVH, indapamide enhanced NOS activity and decreased oxidative damage in the case of the combined treatment. It is concluded that the complex protective effects of the combined indapamide plus captopril treatment on hypertension may be exerted via its effects on blood pressure, hypertrophy and vasorelaxation. |
| | |
Authors:
|
Stanislava Vrankov?; Lydia Jendekova; Ludovit Paulis; Martina Sladkova; Fedor Simko; Olga Pechanova |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 27 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-07-27 Completed Date: 2009-11-16 Revised Date: 2010-05-18 |
Medline Journal Info:
|
Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: England |
Other Details:
|
Languages: eng Pagination: S42-6 Citation Subset: IM |
Affiliation:
|
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic. stanislava.kojsova@savba.sk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
metabolism Animals Antihypertensive Agents / pharmacology Blood Pressure Captopril / pharmacology* Femoral Artery / pathology Hypertension / drug therapy* Hypertrophy, Left Ventricular / pathology* Indapamide / pharmacology* Kidney / drug effects Nitric Oxide Synthase / metabolism Rats Rats, Inbred SHR Rats, Inbred WKY Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 26807-65-8/Indapamide; 51-84-3/Acetylcholine; 62571-86-2/Captopril; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The protective effect of irbesartan in rats fed a high fat diet is associated with modification of l...
Next Document: Hypertension and kidney alterations in rat offspring from low protein pregnancies.