Document Detail


Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension.
MedLine Citation:
PMID:  19633451     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The effects of indapamide, a thiazide-like diuretic, and captopril, an angiotensin-converting enzyme inhibitor, on spontaneous hypertension and the development of left ventricular hypertrophy (LVH), nitric oxide generation and oxidant status were investigated. METHODS: Six-week-old male spontaneously hypertensive rats (SHR) were treated with indapamide (1 mg/kg per day) or captopril (10 mg/kg per day) or a combination of indapamide plus captopril. After the 6-week treatment, nitric oxide synthase (NOS) activity, the expression of NOS isoform proteins, conjugated dienes concentration and relaxation responses of the femoral artery were analyzed. RESULTS: Indapamide and captopril partly prevented a blood pressure increase in young SHR. Captopril in contrast to indapamide reduced LVH. The effect of the combined indapamide and captopril treatment on the prevention of hypertension was additive. Combined indapamide and captopril treatment increased NOS activity and endothelial NOS protein expression in the aorta and decreased conjugated dienes concentration in the kidney compared with the indapamide monotherapy group. Indapamide and indapamide and captopril treatment increased acetylcholine-induced relaxation of the femoral artery. CONCLUSION: Whereas captopril reduced LVH, indapamide enhanced NOS activity and decreased oxidative damage in the case of the combined treatment. It is concluded that the complex protective effects of the combined indapamide plus captopril treatment on hypertension may be exerted via its effects on blood pressure, hypertrophy and vasorelaxation.
Authors:
Stanislava Vrankov?; Lydia Jendekova; Ludovit Paulis; Martina Sladkova; Fedor Simko; Olga Pechanova
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  27     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-11-16     Revised Date:  2010-05-18    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  S42-6     Citation Subset:  IM    
Affiliation:
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic. stanislava.kojsova@savba.sk
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism
Animals
Antihypertensive Agents / pharmacology
Blood Pressure
Captopril / pharmacology*
Femoral Artery / pathology
Hypertension / drug therapy*
Hypertrophy, Left Ventricular / pathology*
Indapamide / pharmacology*
Kidney / drug effects
Nitric Oxide Synthase / metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 26807-65-8/Indapamide; 51-84-3/Acetylcholine; 62571-86-2/Captopril; EC 1.14.13.39/Nitric Oxide Synthase

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