| Comparison of the effects of hypothermia at 33 degrees C or 35 degrees C after cardiac arrest in rats. | |
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MedLine Citation:
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PMID: 17296802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Hypothermia of 32 degrees C-34 degrees C induced after resuscitation from cardiac arrest improves neurologic recovery, but the optimal depth of cooling is unknown. Using a rat model, the authors tested the hypothesis that cooling to 35 degrees C between hours 1 and 24 after resuscitation would improve neurologic outcome as much as cooling to 33 degrees C. METHODS: Halothane-anesthetized rats (n = 38) underwent 8 minutes of asphyxial cardiac arrest and resuscitation. Cranial temperature was maintained at 37 degrees C before, during, and after arrest. Between one and 24 hours after resuscitation, cranial temperature was maintained at 33 degrees C, 35 degrees C, or 37 degrees C using computer-controlled cooling fans and heating lamps. Neurologic scores were measured daily, and rats were killed at 14 days for histologic analysis. Neurons per high-powered field were counted in the CA1 region of the anterior hippocampus using neuronal nuclear antigen staining. RESULTS: After 14 days, 12 of 12 rats (100%) cooled to 33 degrees C, 11 of 12 rats (92%) cooled to 35 degrees C, and ten of 14 rats (71%) cooled to 37 degrees C survived, with hazard of death greater in the rats cooled to 37 degrees C than in the combined hypothermia groups. Neurologic scores were worse in the rats cooled to 37 degrees C than in the hypothermia groups on days 1, 2, and 3. Numbers of surviving neurons were similar between the groups cooled to 33 degrees C and 35 degrees C and were higher than in the group cooled to 37 degrees C. CONCLUSIONS: These data illustrate that hypothermia of 35 degrees C or 33 degrees C over the first day of recovery improves neurologic scores and neuronal survival after cardiac arrest in rats. The benefit of induced hypothermia of 35 degrees C appears to be similar to the benefit of 33 degrees C. |
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Authors:
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Eric S Logue; Melissa J McMichael; Clifton W Callaway |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-02-12 |
Journal Detail:
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Title: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine Volume: 14 ISSN: 1553-2712 ISO Abbreviation: Acad Emerg Med Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-02 Completed Date: 2007-05-04 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9418450 Medline TA: Acad Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 293-300 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Ischemia / physiopathology*, prevention & control* Heart Arrest / physiopathology* Hypothermia, Induced / methods* Male Proportional Hazards Models Rats Rats, Sprague-Dawley Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS046073/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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