Document Detail

Comparison of the effects of high frequency oscillation and controlled mechanical ventilation on hyaline membrane formation in a rabbit model of the neonatal respiratory distress syndrome.
MedLine Citation:
PMID:  2502167     Owner:  NLM     Status:  MEDLINE    
Saline lavage of the lungs of eight anaesthetized New Zealand White rabbits was performed to produce a surfactant-depletion model of the neonatal respiratory distress syndrome. A characteristic change in the shape of the pressure-volume curve occurred, with the appearance of an inflection point on the inspiratory limb. The animals were treated with high frequency oscillation (HFO) at 15 Hz and the results compared with those of a previously studied group of eight similar rabbits treated with controlled mechanical ventilation (CMV) with end-expiratory pressure equal to the pressure at the inflection point, but with the same mean airway pressure of 15 mm Hg. The animals treated with HFO had significantly higher arterial oxygen tensions and end-expiratory lung volumes than those treated with CMV, but there was no significant difference between hyaline membrane scores. Although there was no significant difference in mean survival times, five of the HFO treated animals showed reversion of the shape of their pressure-volume curves towards the prelavage configuration, suggesting a recovery of surfactant function.
D J Niblett; B K Sandhar; M S Dunnill; M K Sykes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  62     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-06     Completed Date:  1989-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  628-36     Citation Subset:  IM    
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford.
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MeSH Terms
Carbon Dioxide / blood,  physiology
Disease Models, Animal
High-Frequency Ventilation*
Hyaline Membrane Disease / mortality,  physiopathology,  therapy*
Infant, Newborn
Lung / physiopathology
Oxygen / blood,  physiology
Positive-Pressure Respiration
Respiration, Artificial*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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