Document Detail


Comparison of the effects of a high-fat and high-carbohydrate soup delivered orally and intragastrically on gastric emptying, appetite, and eating behaviour.
MedLine Citation:
PMID:  10477062     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the effects of fat and carbohydrate on appetite, food intake and gastric emptying with and without the influence of orosensory factors, a group of nine healthy, fasted male subjects took part in two separate paired experiments involving high-fat and high-carbohydrate radiolabelled soup preloads. In the first experiment subjects received direct intragastric isocaloric infusions of either a high-fat tomato soup or a high-carbohydrate tomato soup (400 kcal in 425 mL) over 15 min, on two occasions. In the second paired experiment subjects ingested the same high-fat and high-carbohydrate soup over 15 min. In both experiments ratings of hunger and fullness were recorded over a period of 135 min and gastric emptying was measured by scintigraphy. Food intake was evaluated from a test meal (yoghurt drink) given 2 h after the end of the soup infusion/ingestion. When soup was administered intragastrically (Experiment 1) both the high-fat and high-carbohydrate soup preloads suppressed appetite ratings from baseline, but there were no differences in ratings of hunger and fullness, food intake from the test meal, or rate of gastric emptying between the two soup preloads. When the same soups were ingested (Experiment 2), the high-fat soup suppressed hunger, induced fullness, and slowed gastric emptying more than the high-carbohydrate soup and also tended to be more effective at reducing energy intake from the test meal. The results of these studies demonstrate that orosensory stimulation plays an important role in appetite regulation, and also indicate that subtle differences in orosensory stimulation produced by particular nutrients may profoundly influence appetite and gastrointestinal responses.
Authors:
J E Cecil; J Francis; N W Read
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  67     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-12-17     Completed Date:  1999-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM    
Affiliation:
Centre for Human Nutrition, University of Sheffield, Northern General Hospital, UK. Cecil@monell.org
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Appetite Regulation / drug effects*,  physiology
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Eating / drug effects,  physiology
Energy Intake / drug effects,  physiology
Enteral Nutrition / methods
Feedback
Feeding Behavior / drug effects*,  physiology
Gastric Emptying / drug effects*,  physiology
Humans
Hunger / drug effects,  physiology
Intubation, Gastrointestinal
Male
Mouth / physiology
Satiation / drug effects*,  physiology
Sensation / physiology
Time Factors
Chemical
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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