Document Detail

Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers.
MedLine Citation:
PMID:  12184702     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of 4 antiarrhythmic treatment protocols on number of ventricular premature complexes (VPC), severity of arrhythmia, heart rate (HR), and number of syncopal episodes in Boxers with ventricular tachyarrhythmias. DESIGN: Randomized controlled clinical trial. ANIMALS: 49 Boxers. PROCEDURE: Dogs with > 500 VPC/24 h via 24-hour ambulatory ECG (AECG) were treated with atenolol (n = 11), procainamide (11), sotalol (16), or mexiletine and atenolol (11) for 21 to 28 days. Results of pre- and posttreatment AECG were compared with regard to number of VPC/24 h; maximum, mean, and minimum HR; severity of arrhythmia; and occurrence of syncope. RESULTS: Significant differences between pre- and posttreatment number of VPC, severity of arrhythmia, HR variables, or occurrence of syncope were not observed in dogs treated with atenolol or procainamide. Significant reductions in number of VPC, severity of arrythmia, and maximum and mean HR were observed in dogs treated with mexiletine-atenolol or sotalol; occurrence of syncope was not significantly different between these 2 treatment groups. CONCLUSIONS AND CLINICAL RELEVANCE: Treatment with sotalol or mexiletine-atenolol was well tolerated and efficacious. Treatment with procainamide or atenolol was not effective.
Kathryn M Meurs; Alan W Spier; Nicola A Wright; Clarke E Atkins; Teresa C DeFrancesco; Sonya G Gordon; Robert L Hamlin; Bruce W Keene; Matthew W Miller; N Sydney Moise
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  221     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-19     Completed Date:  2002-11-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-7     Citation Subset:  IM    
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
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MeSH Terms
Anti-Arrhythmia Agents / pharmacology,  therapeutic use*
Arrhythmias, Cardiac / drug therapy,  veterinary*
Atenolol / therapeutic use
Dog Diseases / drug therapy*
Drug Therapy, Combination
Heart Rate
Mexiletine / therapeutic use
Procainamide / therapeutic use
Random Allocation
Sotalol / therapeutic use
Syncope / drug therapy,  veterinary*
Treatment Outcome
Ventricular Premature Complexes / drug therapy,  veterinary*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 29122-68-7/Atenolol; 31828-71-4/Mexiletine; 3930-20-9/Sotalol; 51-06-9/Procainamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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