Document Detail

Comparison of effects of fentanyl and alfentanil on intra-ocular pressure. A double-blind controlled trial.
MedLine Citation:
PMID:  3089049     Owner:  NLM     Status:  MEDLINE    
The effects of fentanyl and alfentanil on intra-ocular pressure during anaesthesia were investigated in 50 consecutive patients in a double-blind controlled trial. Both drugs produced a significant reduction in intraocular pressure (p less than 0.01). Alfentanil produced significantly greater reduction (48.5 percent) than fentanyl (28.6 percent) (p less than 0.01). A small but statistically significant reduction in arterial pressure (15 percent approximately) and heart rate (18 percent approximately), were observed with both agents, but no significant differences between them were noted. It is suggested that alfentanil may be a suitable alternative to fentanyl in ophthalmic anaesthesia.
S M Mostafa; A Lockhart; D Kumar; M Bayoumi
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  41     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-25     Completed Date:  1986-07-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  493-8     Citation Subset:  AIM; IM    
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MeSH Terms
Adjuvants, Anesthesia / pharmacology*
Clinical Trials as Topic
Double-Blind Method
Fentanyl / analogs & derivatives*,  pharmacology*
Hemodynamics / drug effects
Intraocular Pressure / drug effects*
Middle Aged
Ophthalmologic Surgical Procedures
Time Factors
Reg. No./Substance:
0/Adjuvants, Anesthesia; 437-38-7/Fentanyl; 71195-58-9/Alfentanil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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