Document Detail

Comparison of the effects of extradural clonidine with those of morphine on postoperative pain, stress responses, cardiopulmonary function and motor and sensory block.
MedLine Citation:
PMID:  2513858     Owner:  NLM     Status:  MEDLINE    
We have examined the effects of extradural clonidine 150 micrograms or morphine 4 mg on postoperative pain, stress responses, cardiopulmonary function and motor and sensory block in a double-blind, randomized study in 20 patients undergoing hysterectomy with general anaesthesia. Observations were made for 6 h after each patient's first request for analgesia. Clonidine provided greater pain relief than morphine only for the first 2 h of observation (P less than 0.001). Plasma cortisol concentrations decreased to a greater extent (P less than 0.05) with morphine, while plasma glucose concentration increased by a similar extent in both groups. After clonidine, mean arterial pressure decreased from 100 (SEM 3) mm Hg to 70 (3) mm Hg (P less than 0.05), but there was no change after morphine. There were no significant changes in heart rate, pulmonary function (FEV1), motor function or sensory analgesia to touch, temperature and pinprick in both groups. Additional systemic opioids were required by five and six patients in the clonidine and morphine groups, respectively.
C Lund; S Qvitzau; A Greulich; N C Hjortsø; H Kehlet
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  63     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-13     Completed Date:  1990-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  516-9     Citation Subset:  IM    
Department of Anaesthesiology, Hvidovre University Hospital, Copenhagen, Denmark.
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MeSH Terms
Analgesia, Epidural*
Blood Glucose / analysis
Blood Pressure / drug effects
Carbon Dioxide / blood
Clonidine / pharmacology*
Double-Blind Method
Forced Expiratory Volume / drug effects
Heart Rate / drug effects
Hydrocortisone / blood*
Middle Aged
Morphine / pharmacology*
Nerve Block
Pain, Postoperative / drug therapy*
Randomized Controlled Trials as Topic
Sensation / drug effects
Reg. No./Substance:
0/Blood Glucose; 124-38-9/Carbon Dioxide; 4205-90-7/Clonidine; 50-23-7/Hydrocortisone; 57-27-2/Morphine

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